Correlation analysis of kisspeptin and omentin-1 expression with bone age index and ovarian volume in girls with central precocious puberty

Zheng Xinyue; Jiao Jiao; Zhang Xuesong

doi:10.3760/j.issn.1673-4777.2024.06.020

Abstract：Objective To investigate the correlation between the expression of kisspeptin and omentin-1 and bone age index and ovarian volume in girls with central precocious puberty.Methods A total of 85 girls with central precocious puberty who were treated in Maternal and Child Health Hospital of Tangshan City,Hebei Province from July 2022 to June 2023 were selected as the observation group,and another 70 healthy girls who underwent physical examination during the same period were selected as the control group.The levels of related clinical indexes,kisspeptin and omentin-1 were compared between the two groups.Logistic regression analysis was used to analyze the influencing factors of bone age index and ovarian volume.Pearson correlation analysis was used to analyze the correlation between the expression of kisspeptin and omentin-1 with bone age index and ovarian volume in girls with central precocious puberty.Results The levels of kisspeptin,bone age index and ovarian volume in the observation group were significantly higher/greater than those in the control group[(2.68±1.05)μg/L vs(0.60±0.20)μg/L,(1.67±0.25)vs(1.02±0.06),(3.68±0.58)cm3 vs(2.70±0.29)cm3],while the level of omentin-1 in the observation group was significantly lower than that in the control group[(27±4)μg/L vs(70±8)µg/L](all P＜0.001).Multivariate Logistic regression analysis showed that predicting adult height,estradiol,luteinizing hormone(LH),follicle stimulating hormone(FSH),bone-derived alkaline phosphatase,osteocalcin,insulin-like growth factor-1,kisspeptin and omentin-1 were the influencing factors of bone age index(all P＜0.001),while uterine volume,estradiol,LH,FSH,kisspeptin and omentin-1 were the influencing factors of ovarian volume(all P＜0.001).Kisspeptin in girls with central precocious puberty was positively correlated with bone age index(r=0.634,P=0.001)and ovarian volume(r=0.533,P=0.001),and the omentin-1 was negatively correlated with bone age index(r=-0.569,P=0.001)and ovarian volume(r=-0.459,P=0.001).Conclusion The expression of kisspeptin increases in girls with central precocious puberty,while the expression of omentin-1 decreases.Kisspeptin is positively correlated with the bone age index and ovarian volume of pediatric patients,while omentin-1 is negatively correlated with the bone age index and ovarian volume of pediatric patients.