Meta-analysis of the incidence of peripherally inserted central catheter-related thrombosis in neonates
Zhong Xuehong
Wang Jingjing
Wu Xuhong
Wang Juan
Abstract：Objective To systematically evaluate the incidence of peripherally inserted central catheter(PICC)-related thrombosis in neonates.Methods Medline,Embase,Web of Science,CINAHL,China Biology Medicine Disc,China National Knowledge Infrastructure,VIP Database and Wanfang Database were searched for studies on the incidence of PICC-related thrombosis in neonates by computers.The search time limit was from the establishment of the database to May 17,2022.After screening and quality evaluation by two reviewers,Meta-analysis was performed using Stata 16.0 software.Results A total of 5 studies were included,with a total sample size of 4 573 cases,among which 104 cases of PICC-related thrombosis occurred.Meta-analysis showed that the incidence of PICC-related thrombosis in neonates was 1.7％(95％confidence interval:0.5％-3.6％).The results of subgroup analysis showed that the incidence of PICC-related thrombosis in neonates published from 2017 to 2021 and those with catheterization through the lower extremity vein was higher.Conclusion The incidence of PICC-related thrombosis in neonates is 1.68％.The incidence of thrombosis is higher in neonates with lower extremity venous catheterization.Therefore,for neonates with coagulopathy and high risk of thrombosis,lower extremity venous catheterization should be avoided.
Keywords：Venous thrombosisNeonatesPeripherally inserted central catheterMeta-analysis
Publication Date：2024-06-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 884-887 )