Meta-analysis of the efficacy and safety of live combined bacillus subtilis enteric-coated capsules in the treatment of irritable bowel syndrome
Wei Qilu
Zhang Shuang
Zhang Xiangrong
Zhang Junhai
Zhang Yanli
Du Shiyu
Abstract：Objective To evaluate the efficacy and safety of live combined bacillus subtilis enteric-coated capsules in the treatment of irritable bowel syndrome(IBS)by Meta-analysis.Methods PubMed,Embase,CBM,CNKI,Wanfang,VIP,Cochrane Library and other databases were systematically searched until June 2023.The observation group was treated with live combined bacillus subtilis enteric-coated capsules alone or combined with other drugs,and the control group was treated with other drugs alone or combined.RevMan 5.4.1 software was used for Meta-analysis.Results Meta-analysis showed that the total effective rate of the observation group was better than that of the control group(relative risk=1.20,P＜0.001),and the incidences of abdominal pain and diarrhea symptoms were lower than those of the control group(all P＜0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(odds ratio=0.80,P=0.28).Subgroup analysis showed that the total effective rates of the observation group were higher than those of the control group in diarrhea-predominant IBS and constipation-predominant IBS(both P＜0.05).Conclusion Based on the current literature evidence,live combined bacillus subtilis enteric-coated capsules are effective and safe in the treatment of IBS.
Keywords：Irritable bowel syndromeLive combined bacillus subtilis enteric-coated capsulesMeta-analysis
Publication Date：2024-06-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 847-852 )