Relationship between left atrial strain and N-terminal pro-brain natriuretic peptide level in ST-segment elevation myocardial infarction patients with mildly reduced or preserved left ventricular ejection fraction
Lyu Sai
Mei Yingchen
Han Rui
Ma Zhan
Wang Jihong
Zhao Xingshan
Lei Hailing
Liu Wei
Abstract：Objective To investigate the relationship between left atrial strain and N-terminal pro-brain natriuretic peptide(NT-proBNP)level in ST-segment elevation myocardial infarction(STEMI)patients with mildly reduced or preserved left ventricular ejection fraction(LVEF).Methods Patients who were first diagnosed with acute STEMI and underwent percutaneous coronary intervention(PCI)within 24 h from March to December 2022 in Department of Cardiology,Beijing Jishuitan Hospital,Capital Medical University,with LVEF＞40％in the acute phase,were enrolled.The left atrial strain parameters were analyzed by two-dimensional speckle tracking imaging.According to the value of left atrial strain during reservoir phase(LASr),patients were divided into reduced LASr group and normal LASr group.The clinical data and ultrasound data of the two groups were compared.Multiple linear regression model was used to analyze the relationship between LASr and serum NT-proBNP peak value in STEMI patients with mildly reduced or preserved LVEF.Results Among 51 patients with acute STEMI and LVEF＞40％who underwent PCI,there were 22 cases(43.1％)in reduced LASr group and 29 cases(56.9％)in normal LASr group.Age and NT-proBNP peak value in the reduced LASr group were higher than those in the normal LASr group[(60±12)years vs(50±12)years,1 679.0(811.4,2 133.2)ng/L vs 584.2(201.5,1 524.0)ng/L](both P＜0.05).The longitudinal strain during left atrial channel phase and strain during left atrial systolic phase in the reduced LASr group were higher than those in the normal LASr group(both P＜0.05).Multiple linear regression analysis showed that after adjusting for anterior myocardial infarction,peak value of creatine kinase isoenzyme and LVEF,LASr was an independent predictor of serum NT-proBNP peak value in STEMI patients with mildly reduced or preserved LVEF(P=0.039).Conclusion LASr is an independent predictor of NT-proBNP peak value in STEMI patients with mildly reduced or preserved LVEF undergoing PCI.
Keywords：Acute ST-segment elevation myocardial infarctionPercutaneous coronary interventionLeft atrial strainN-terminal pro-brain natriuretic peptide
Publication Date：2024-06-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 815-819 )