Effect of Mongolian medicine Qingxue Bawei powder combined with amlodipine besvlate on hemorheology in patients with essential hypertension

Narenmandula; Bao Xiaoqing; Yang Aomin

doi:10.3760/j.issn.1673-4777.2024.05.019

Abstract：Objective To investigate the effect of Mongolian medicine Qingxue Bawei powder combined with amlodipine besylate on hemorheology and related indexes in patients with essential hypertension.Methods Patients with essential hypertension who were treated in People's Hospital of Inner Mongolia Autonomous Region from March 2021 to February 2023 were selected.According to the random number table method,they were divided into the observation group(31 cases)and the control group(29 cases).The control group was treated with amlodipine besylate tablets,and the observation group was treated with Qingxue Bawei powder on the basis of the control group.Both groups were treated for 30 d.The changes of hemorheology,blood lipid,homocysteine(Hcy),high-sensitive C-reaction protein(hs-CRP),blood pressure level and safety indexes were observed before and after treatment.Results After treatment,whole blood high-resection relative index,whole blood low-resection relative index,plasma viscosity and erythrocyte aggregation index in the observation group were improved compared with those before treatment,and the improvement of whole blood high-resection relative index and whole blood low-resection relative index were greater than those in the control group[3.04(0.89,5.51)vs 0.69(0.13,1.93),5.22(2.83,8.97)vs 2.64(1.34,5.19)](all P＜0.05).After treatment,the levels of high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),total cholesterol and triacylglycerol in the observation group were all improved compared with those before treatment,and the levels of HDL-C,LDL-C and triacylglycerol were improved more than those in the control group(all P＜0.05).After treatment,the levels of Hcy,hs-CRP,systolic blood pressure and diastolic blood pressure in the observation group were all improved,and the improvement of Hey,hs-CRP and diastolic blood pressure were greater than those in the control group(all P＜0.05).Before and after treatment,the blood routine and liver and kidney function indexes of the two groups were within the normal range,and there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Mongolian medicine Qingxue Bawei powder combined with amlodipine besylate has a certain improvement effect on hemorheology and related indicators in patients with essential hypertension,and the improvement effect is significantly better than amlodipine besylate alone.