Observation on the therapeutic effect of Duzhong Jiangu granules combined with teripaptide on osteoporosis in elderly women

Cai Rui; Yang Guang

doi:10.3760/j.issn.1673-4777.2024.05.018

Abstract：Objective To explore the therapeutic effect of Duzhong Jiangu granules combined with teriparatide on osteoporosis(OP)in elderly women.Methods Totally 100 elderly female OP patients who were treated in Tangshan Central Hospital,Hebei Province from June 2021 to October 2022 were selected as research subjects.According to the random number table method,they were divided into western medicine group and traditional Chinese and western medicine group,with 50 cases in each group.All patients were treated with basic treatment,and the western medicine group was treated with teriparatide subcutaneous injection on the basis of basic treatment,and the traditional Chinese and western medicine group was treated with oral Duzhong Jiangu granules on the basis of the western medicine group.The bone density,bone metabolism indicators[C-telopeptide of type Ⅰcollagen(CTX-Ⅰ),intact parathyroid hormone(iPTH),tartrate resistant acid phosphatase 5b(TRACP-5b)],traditional Chinese medicine syndrome scores,and serum chemerin levels before treatment and 6 months after treatment were compared between the two groups.At the same time,the efficacy and occurrence of adverse drug reactions(ADR)were compared between the two groups.Results During the study period,2 and 3 cases dropped out in the western medicine group and the traditional Chinese and western medicine group,respectively,48 and 47 cases were finally included in the evaluation,respectively.After 6 months of treatment,the bone density of the 2nd to 4th lumbar vertebrae,femoral neck,and greater trochanter in both groups were higher than those before treatment,and those in the traditional Chinese and western medicine group were significantly higher than those in the western medicine group;the levels of CTX-Ⅰ,iPTH,TRACP-5 b,traditional Chinese medicine syndrome scores and serum chemerin level were lower than those before treatment,and those in the traditional Chinese and western medicine group were significantly lower than those in the western medicine group(all P＜0.05).The total effective rate of the traditional Chinese and western medicine group was significantly higher than that of the western medicine group[95.7％(45/47)vs 81.2％(39/48)](x2=4.873,P=0.027).There was no significant difference in the total incidence of ADR between the two groups(x2=0.080,P=0.777).Conclusion The application of Duzhong Jiangu granules combined with teriparatide in the treatment of elderly female OP patients can improve the anti-OP effect,obviously alleviate symptoms,increase bone density,effectively reduce bone metabolism indicators and serum chemerin level,and has high safety.