Efficacy of ozone combined with low-temperature plasma radiofrequency thermocoagulation on discogenic lumbodynia and its impact on patients'inflammatory factor levels
Huo Yansong
Sun Haiyan
Pang Jinlei
Guo Xiangfei
Liu Yajing
Ran Guangyuan
Fu Zhouyang
He Mingwei
Abstract：Objective To investigate the efficacy of ozone combined with low-temperature plasma radiofrequency thermocoagulation on discogenic lumbodynia and its impact on patients'inflammatory factor levels.Methods A total of 104 patients with discogenic lumbodynia who were treated in the Department of Pain Management,Beijing Anzhen Hospital,Capital Medical University from May 2022 to May 2023 were selected.According to the random number table method,they were divided into control group and observation group,with 52 cases in each group.The control group was treated with low-temperature plasma radiofrequency thermocoagulation,and the observation group was treated with ozone combined with low-temperature plasma radiofrequency thermocoagulation.Clinical efficacy,pain visual analogue scale(VAS)score,Oswestry dysfunction index questionnaire(ODI)score,levels of interleukin-1 β(IL-1β),IL-6,1L-8 and tumor necrosis factor-α(TNF-α)before and after treatment,and incidence of adverse reactions after treatment were compared.Results The excellent rate of the observation group was higher than that of the control group[94.2％(49/52)vs 78.8％(41/52)](P＜0.001).After 2 weeks of treatment,the VAS and ODI scores of the two groups were lower than those before treatment,and those of the observation group were lower than those of the control group[between two groups:(1.4±1.2)vs(2.4±1.0),(13±4)vs(23±5)](both P＜0.001).After 2 weeks of treatment,the levels of serum IL-1 β,IL-6,IL-8 and TNF-α in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(all P＜0.001).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P=1.000).Conclusion Ozone combined with low-temperature plasma radiofrequency thermocoagulation is a safe and effective method for the treatment of discogenic lumbodynia,which can significantly reduce the levels of inflammatory factors.
Keywords：Discogenic lumbodyniaOzoneLow-temperature plasma radiofrequency thermocoagulationInflammatory response
Publication Date：2024-05-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 723-727 )