The diagnostic value of superb microvascular imaging combined with contrast-enhanced ultrasound in thyroid micropapillary carcinoma

Pu Tianning; Zheng Chao; Zhang Yiran; Zhao Qing

doi:10.3760/j.issn.1673-4777.2024.05.014

Abstract：Objective To evaluate the diagnostic value of superb microvascular imaging(SMI),contrast-enhanced ultrasound(CEUS)and both combination in thyroid micropapillary carcinoma(TMC).Methods Totally 45 patients with suspected TMC were examined by ultrasound,SMI and CEUS,and then underwent surgical resection in Beijing Anzhen Hospital,Capital Medical University from July 2017 to September 2023.The pathological results were obtained.Pathological diagnosis was used as a golden indicator,and the diagnostic value of SMI,CEUS and SMI combined with CEUS in TMC was compared.Results Among 45 patients,55 thyroid nodules were detected.SMI found 44 malignant thyroid nodules and 11 benign thyroid nodules,and the SMI diagnosis of TMC had a conformity rate of 89.1％,sensitivity of 100％,specificity of 45.5％,misdiagnosis rate of 54.5％,missed diagnosis rate of 0,positive predictive value of 88％,negative predictive value of 100％,and Kappa value of 0.571.CEUS found 49 malignant nodules and 6 benign nodules,and the CEUS diagnosis of TMC had a coincidence rate of 94.5％,sensitivity of 98.0％,specificity of 66.7％,misdiagnosis rate of 33.3％,missed diagnosis rate of 2.0％,positive predictive value of 96％,negative predictive value of 80％,and Kappa value of 0.697.SMI combined with CEUS found 48 malignant thyroid nodules and 7 benign thyroid nodules,and SMI combined with CEUS diagnosis of TMC had a coincidence rate of 96.4％,sensitivity of 100％,specificity of 71.4％,misdiagno-sis rate of 28.6％,missed diagnosis rate of 0,positive predictive value of 96％,negative predictive value of 100％,and Kappa value of 0.814.Conclusion The diagnostic coincidence rate of SMI combined with CEUS is higher than that of single SMI and CEUS.SMI can be used as a preliminary screening method for TMC patients.