Clinical study on the combination of Jieyu Anshen granules and olanzapine in the treatment of schizophrenia patients with mild anxiety and depression
Zhao Shuncheng
Dong Xiang
Li Shengyan
Bai Shucun
Li Shaohua
Abstract：Objective To explore the clinical efficacy of Jieyu Anshen granule combined with olanzapine in the treatment of schizophrenia with mild anxiety and depression.Methods A total of 102 schizophrenia patients with mild anxiety and depression who were treated in the Third People's Hospital of Qinghai Province from January 2020 to December 2022 were selected.They were randomly divided into observation group(51 cases)and control group(51 cases).On the basis of routine psychological counseling,the control group was treated with olanzapine tablets,and the observation group was treated with Jieyu Anshen granules on the basis of the control group.The total effective rate was compared between the two groups after 2 months of treatment.The positive and negative syndrome scale(PANSS)score,Loewenstein occupational therapy cognitive assessment(LOTCA)score,self-rating anxiety scale(SAS)score and self-rating depression scale(SDS)score before and after treatment were recorded and compared between the two groups.The adverse reactions of the two groups were recorded and compared.Results The total effective rate of the observation group was higher than that of the control group[88.2％(45/51)vs 70.6％(36/51)](P＜0.05).After treatment,the PANSS score,SAS score and SDS score of the two groups were significantly lower than those before treatment,and the LOTCA score was significantly higher than that before treatment.The PANSS score,SAS score and SDS score of the observation group were lower than those of the control group,and the LOTCA score was higher than that of the control group(all P＜0.05).After treatment,the levels of serum melatonin and 5-hydroxytryptamine in the two groups were significantly higher than those before treatment,and those in the observation group were higher than those in the control group(all P＜0.05).The incidence of adverse reactions was compared between the observation group and the control group[15.7％(8/51)vs 23.5％(12/51)](P=0.318).Conclusion Jieyu Anshen granule combined with olanzapine in the treatment of schizophrenia with mild anxiety and depression has a good effect,which can improve the mental state and cognitive function of patients,reduce the degree of anxiety and depression,and the safety is good.
Keywords：SchizophreniaAnxietyDepressionJieyu Anshen granulesOlanzapine
Publication Date：2024-05-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 704-708 )