Correlation research between serum uric acid level and atrial fibrillation in patients with non-alcoholic fatty liver disease
Zhang Qi
Li Baojie
Zhou Meng
Liu Gaizhen
Abstract：Objective To investigate the correlation between serum uric acid level and atrial fibrillation in patients with non-alcoholic fatty liver disease(NAFLD).Methods A total of 565 patients diagnosed with NAFLD in the Second Hospital of Shanxi Medical University from January 2020 to December 2022 were retrospectively selected.According to whether they were complicated with atrial fibrillation,they were divided into atrial fibrillation group(224 cases)and non-atrial fibrillation group(341 cases).The clinical data of the two groups were analyzed.Multivariate Logistic regression analysis was used to determine the related factors for the occurrence of atrial fibrillation in NAFLD patients.A trend test was used to analyze the linear trend between serum uric acid level and atrial fibrillation.The nomogram model was constructed to predict the risk of atrial fibrillation,and the calibration curve was drawn to evaluate the accuracy of the nomogram.Finally,the receiver operating characteristic(ROC)curve was drawn to evaluate the predictive value of serum uric acid and the nomogram model for the occurrence of atrial fibrillation in NAFLD patients.Results Multivariate Logistic regression analysis showed that age[odds ratio(OR)=1.096,95％confidence interval(CI):1.071-1.121,P＜0.001],serum creatinine(OR=1.021,95％CI:1.003-1.039,P=0.025)and serum uric acid(OR=1.008,95％CI:1.005-1.011,P＜0.001)were independent risk factors for the occurrence of atrial fibrillation in NAFLD patients,and high-density lipoprotein(P=0.010)was an independent protective factor.The risk of atrial fibrillation increased with the increase of serum uric acid level(P＜0.001 for trend test).The C-index of the nomogram predicted atrial fibrillation was 0.827(95％CI:O.793-0.861),and the Hosmer-Lemeshow test and calibration plots showed that the model was well calibrated.ROC analysis showed that the area under the curve of the nomogram model was 0.827,which was better than that of serum uric acid(0.683).Conclusion Elevated serum uric acid level is an independent risk factor for atrial fibrillation in patients with NAFLD.
Keywords：Non-alcoholic fatty liver diseaseAtrial fibrillationSerum uric acidOxidative stress
Publication Date：2024-05-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 684-688 )