Observation on the effect of Shugan Jianpi Busui decoction on prevention and treatment of blood toxicity caused by poly(adenosine diphosphate-ribose)polymerase inhibitors in maintenance treatment of ovarian cancer
Dai Bo
Yao Changju
Zheng Lei
Wu Yue
Zhang Mei
Abstract：Objective To observe the effect of Shugan Jianpi Busui decoction on prevention and treatment of blood toxicity caused by poly(adenosine diphosphate-ribose)polymerase inhibitor(PARPi)in maintenance treatment of ovarian cancer.Methods A total of 60 patients with ovarian cancer who met the inclusion criteria were enrolled in the Oncology Department of Integrated Traditional Chinese and Western Medicine and the Department of Medical Consortium of the First Affiliated Hospital of Anhui Medical University from August 2021 to December 2023 were selected,and they were divided into observation group(30 cases)and control group(30 cases)according to the random number table method.The control group was treated with PARPi maintenance treatment,and the observation group was treated with Shugan Jianpi Busui decoction on the basis of the control group.After 3 months of treatment,the incidence,severity,duration,traditional Chinese medicine(TCM)syndrome score,efficacy and adverse reactions of the two groups were compared.Results After 3 months of treatment,the incidence and severity of anemia,thrombocytopenia and neutropenia in the observation group were lower than those in the control group[26.7％(8/30)vs 53.3％(16/30),23.3％(7/30)vs 50.0％(15/30),20.0％(6/30)vs 46.7％(14/30)](all P＜0.05).The duration of anemia and thrombocytopenia in the observation group were shorter than those in the control group[(2.56±1.33)d vs(4.21±2.00)d,(7.33±0.38)d vs(9.26±1.22)d](both P＜0.05).After 3 months of treatment,the TCM syndrome score of the observation group was significantly lower than that of the control group,and the TCM syndrome curative effect was better than that of the control group(both P＜0.05).The incidence of nausea and vomiting,diarrhea and constipation in the observation group were lighter than those in the control group(all P＜0.05).Conclusion Shugan Jianpi Busui decoction can reduce the incidence and severity of blood toxicity,shorten the occurrence time,improve the efficacy of TCM syndromes,and maintain the persistence of response to PARPi treatment.
Keywords：Ovarian cancerShugan Jianpi Busui decoctionPoly(adenosine diphosphate-ribose)polymerase inhibitorBlood toxicity
Publication Date：2024-05-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 664-668 )