Theoretical exploration and analysis of Yiqi Huoxue Jiedu method based on immune-inflammatory microenvironment on promoting the transformation of ovarian cancer from"cold"to"hot"
Mei Heting
Lu Wenping
Jiang Yici
Song Qingya
Chang Lei
Abstract：Ovarian cancer is a gynecological malignant tumor with the highest mortality rate.Exploring effective treatment methods to prevent metastasis has become an urgent clinical problem to be solved.Immunotherapy is a new field of cancer treatment.However,ovarian cancer is not sensitive to immunotherapy because of the lack of infiltration of cytotoxic T cells and the inability of infiltrated T cells to recognize all tumor antigens.It belongs to the category of"cold tumor"and is not sensitive to immunotherapy.Traditional Chinese medicine believes that qi deficiency,blood stasis and toxic turbidity are the key pathogenesis of ovarian cancer,and the Yiqi Huoxue Jiedu method is an important treatment,which needs to be further clarified on the basis of theoretical research.Immuno-suppression and chronic inflammation constitute the two core characteristics of the tumor microenvironment,which jointly promote the occurrence,development and metastasis of tumors.In this paper,the immune-inflammatory microenvironment is highly consistent with the theory of"Yin and Yang"and"poison-pathogenic factors"of traditional Chinese medicine.The deficiency of Yang transforming qi is like the deficiency of positive immune cells such as cytotoxic T cells.On the one hand,it is like infiltration of too many immunosuppressive cells,factors,and metabolites.On the other hand,it is like poison caused by deficiency in the human body,which maintains and amplifies the inflammatory microenvironment.Inflammation promotes tumor progression,and inflammation in turn promotes immunosuppression.The therapeutic idea of this method is clarified from the perspective of immune inflammation:"warming Yang,strengthening positive,balancing Yin and Yang"to activate positive immunity."Activating blood circulation,dissipating phlegm,dispersing cold and clearing heat"can disperse Yin and pathogenic factors,detoxify toxic stagnation,thereby alleviating immunosuppression and regulating inflammatory microenvironment.The anti-inflammatory treatment by"Fighting poison with poison"improves the theoretical basis for the transformation of"cold"and"hot"immunogenicity by this method,and provides theoretical basis for further material research.
Keywords：Ovarian cancerYiqi Huoxue Jiedu methodCold tumorImmune-inflammatory micro-environmentTraditional Chinese medicine
Publication Date：2024-05-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 649-653 )