Effects of sugammadex on hemodynamics and related complications in patients undergoing periextubation period of laparoscopic cholecystectomy

Ji Yanan; Chen Kai; Li Xiaofang

doi:10.3760/j.issn.1673-4777.2024.04.017

Abstract：Objective To investigate the effects of sugammadex on hemodynamics and related complications in patients undergoing periextubation period of laparoscopic cholecystectomy.Methods Totally 120 patients with laparoscopic cholecystectomy admitted to the Fifth Affiliated Hospital of Xinjiang Medical University from June 2019 to June 2022 were selected.They were randomly divided into the control group and the observation group,with 60 cases in each group.The control group was not given the muscle relaxant antagonist after the operation,and the observation group was given sugammadex intravenous drip after the operation.The heart rate,systolic blood pressure and diastolic blood pressure of the two groups were compared during periextubation period.The serum levels of adrenocorticotropic hormone(ACTH)and cortisol were compared between the two groups before and immediately after operation.The extubation time,the recovery time of train of four stimulation count(TOF),the length of stay in the post-anesthesia care unit(PACU),and incidences of hypoxemia and arrhythmia were compared between the two groups.Results The heart rate,systolic blood pressure and diastolic blood pressure of the control group were higher at 1,5 and 10 min after extubation than before extubation(all P＜0.05).There were no significant differences in heart rate,systolic blood pressure and diastolic blood pressure of the observation group between 1,5 and 10 min after extubation and before extubation(all P＞0.05),and the systolic blood pressure and diastolic blood pressure were lower than those of the control group(both P＜0.05).The serum ACTH and cortisol levels immediately after operation in both groups were higher than those before treatment,while the observation group was lower than the control group(all P＜0.05).The postoperative extubation time,TOF recovery time,and PACU time of the observation group were significantly shorter than those of the control group[(2.2± 1.0)min vs(31.1±10.1)min,(55±8)min vs(74±12)min,(35±9)min vs(48±13)min](all P＜0.001).The incidences of postoperative hypoxemia and arrhythmia in the observation group were lower than those in the control group[8.3％(5/60)vs 33.3％(20/60),1.7％(1/60)vs 13.3％(8/60)](both P＜0.05).Conclusion After laparoscopic cholecystectomy,using sugammadex can maintain the hemodynamics of patients,reduce the stress response,and reduce the incidence of complications after extubation.