Analysis of etomidate target-controlled infusion combined with recurrent laryngeal nerve function monitoring in endoscopic thyroid surgery

Long Qianhai; Luo Xibao; Zhang Xu; Lu Min; Qin Binglan; Mi Qiaoqiao

doi:10.3760/j.issn.1673-4777.2024.04.015

Abstract：Objective To explore the effect of etomidate target-controlled infusion combined with recurrent laryngeal nerve function monitoring in endoscopic thyroid surgery.Methods Totally 80 patients diagnosed and underwent endoscopic thyroid surgery in the Second Affiliated Hospital of Guilin Medical University from December 2020 to December 2022 were enrolled.According to the random number method,patients were divided into observation group and control group,with 40 cases in each group.The observation group was given target-controlled infusion of etomidate,and the control group was given target-controlled infusion of propofol.Mechanical ventilation was performed after endotracheal intubation.Meanwhile,recurrent laryngeal nerve function was monitored in both groups.The operation time,postoperative recovery time,time from drug withdrawal to extubation of patients were recorded.Mean arterial pressure(MAP),heart rate and bispectral index(BIS)before anesthesia induction(T0),tracheal intubation(T,)and immediately after tracheal intubation(T2)and adverse reactions after operation were recorded.Results The recovery time and the time from drug withdrawal to extubation in the observation group were shorter than those in the control group[(17±4)min vs(20±4)min,(13.1±2.5)min vs(20.2±2.9)min](both P＜0.001).At T1 and T2,MAP,heart rate and BIS in both groups were lower than those at T0,and the levels in the observation group were higher than those in the control group(all P＜0.001).There was no significant difference in the incidence of adverse reactions between the two groups(P=0.166).Conclusions Etomidate target-controlled infusion combined with recurrent laryngeal nerve function monitoring has a good application effect in endoscopic thyroid surgery.It can not only shorten the postoperative recovery time and the time from drug withdrawal to extubation,but also maintain intraoperative hemodynamic stability.