Effects of different doses of ciprofol on hemodynamics and heart rate variability in elderly patients with trigeminal neuralgia during induction of general anesthesia

Zhang Huanhuan; He Jinhua; Zhang Meng; Zhang Yu; Liu Meinyu; Li Jianli

doi:10.3760/j.issn.1673-4777.2024.04.013

Abstract：Objective To observe the effects of different doses of ciprofol on hemodynamics and heart rate variability in elderly patients with trigeminal neuralgia during induction of general anesthesia.Methods Totally 90 elderly patients with trigeminal neuralgia undergoing percutaneous balloon compression in Hebei General Hospital from February to December 2022 were enrolled.They were divided into low-dose group(group L),medium-dose group(group M)and high-dose group(group H)according to the random number table method and double blind,with 30 cases in each group.Patients in group L,group M and group H were injected ciprofol 0.2,0.3 and 0.4mg/kg intravenously during anesthesia induction,respectively.Heart rate(HR),mean arterial pressure(MAP)and bispectral index(BIS)were recorded before anesthesia induction(T0),before tracheal intubation(T1)and after tracheal intubation(T2).Short-time heart rate variability parameters in frequency domain were collected,including low frequency power(LF),high frequency power(HF)and LF/HFratio.And the occurrence of adverse reactions was recorded at the same time.Results Compared with T0,HR,MAP and BIS were significantly decreased in three groups at T,,and in the group M and group H at T2(all P＜0.05).Compared with T1,HR and MAP in group L were significantly increased at T2(all P＜0.05).At T1 and T2,HR,MAP and BIS in group H were significantly lower than those in group L and group M(all P＜0.05);at T2,HR and MAP in group L were significantly higher than those in group M(all P＜0.05).Compared with T0,LF,HF and LF/HFratio were significantly decreased in three groups at T1 and in group M and group H at T2(all P＜0.05).Compared with T1,LF and LF/HFratio in group L were significantly higher at T2(both P＜0.05).At T,and T2,LF,HF and LF/HFratio in group H were significantly lower than those in group L and group M(all P＜0.05).At T2,LF and LF/HFratio in group L were significantly higher than those in group M(all P＜0.05).The incidence of adverse reactions in group H was significantly higher than that in group L and group M[36.7％(11/30)vs 10.0％(3/30),3.3％(1/30)](x2=169.25,P＜0.01).Conclusions Ciprofol is used for anesthesia induction in elderly patients with trigeminal neuralgia,which can maintain hemodynamic stability and balance of autonomic nervous function.Compared with induction doses of 0.2 mg/kg and 0.4 mg/kg,induction dose of 0.3 mg/kg can be more safely applied to elderly patients with trigeminal neuralgia.