The application effect of dexmedetomidine in patients with hypertensive cerebral hemorrhage during the perioperative period and its effect on inflammation and stress response indicators
Lyu Ruida
Dai Kefang
Du Xiaomin
Zhang Min
Zhang Huijing
Abstract：Objective To investigate the application effect of dexmedetomidine in patients with hypertensive cerebral hemorrhage during the perioperative period and its effect on inflammation and stress response indicators.Methods Totally 112 patients with hypertensive cerebral hemorrhage admitted to Hengshui People's Hospital,Hebei Province from October 2019 to August 2020 were selected as research objects.According to the random number table method,all patients were divided into observation group and control group,with 56 cases in each group.Both groups received hematoma removal surgery.The control group was given routine anesthesia,and the observation group was given dexmedetomidine after hematoma removal surgery on the basis of the control group.The Ramsay sedation score,hemodynamics,inflammatory and stress indexes and adverse reactions after surgery were compared between the two groups.Results At 24 h after surgery,the Ramsay sedation score in the observation group was significantly lower than that in the control group[(3.63±0.21)vs(4.02±0.25)](P＜0.05).At 24 h after surgery,the heart rate and mean arterial pressure levels of both groups were lower than those before surgery,and those in the observation group were lower than those in the control group[(70±6)times/min vs(74±6)times/min,(89±7)mmHg vs(97±7)mmHg](all P＜0.05).At 24 h after surgery,the levels of interleukin-6,high-sensitivity C-reactive protein,tumor necrosis factor-α,malondialdehyde,angiotensin Ⅱ,and renin in the observation group were significantly lower than those in the control group,while the levels of interleukin-10 and superoxide dismutase were significantly higher than those in control group(all P＜0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group[8.9％(5/56)vs 26.8％(15/56)](P＜0.05).Conclusion Dexmedetomidine has a definite sedative and analgesic effect on patients with hypertensive cerebral hemorrhage after hematoma removal surgery,which can maintain hemodynamic stability,reduce the inflammatory response of the body,reduce the levels of angiotensin Ⅱ and renin,which is beneficial to reduce adverse events and promote postoperative recovery.
Keywords：Hypertensive cerebral hemorrhageDexmedetomidineInflammationStress response
Publication Date：2024-04-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 525-529 )