Study on the effect of glycopyrronium bromide and formoterol combined with respiratory training on respiratory function and inflammatory factor levels in stable chronic obstructive pulmonary disease patients

Wang Lei; Chen Zhongren; Liang Haimei; Feng Shu; Wang Shaona; Yang Xuli; Wang Xiaoqiang; Huang Sini; Wang Jieping

doi:10.3760/j.issn.1673-4777.2024.04.007

Abstract：Objective To study the effects of glycopyrronium bromide and formoterol combined with respiratory training on respiratory function and impacts on interleukin-8(IL-8)and phosphodiesterase 4(PDE4)in patients with stable chronic obstructive pulmonary disease(COPD).Methods A total of 100 patients with stable COPD admitted to Haikou People's Hospital,Hainan Province from February 2021 to February 2023 were selected.Patients were divided into control group and observation group according to the random number table method,with 50 cases each.The control group was treated with glycopyrronium bromide and formoterol,and the observation group was treated with respiratory training based on the control group.Both groups were treated for 3 months.Peak flow rate(PEF),forced expiratory volume in the first second(FEV1),FEV1 as a percentage of expected value(FEV1％),COPD assessment test(CAT)score,quality of life score(SGRQ),arterial partial pressure of oxygen(PaO2),arterial blood carbon dioxide partial pressure(PaCO2)and IL-8 and PDE4 levels were compared between the two groups before and after treatment.Results After treatment,PEF,FEV1and FEV1％ in both groups were higher than those before treatment and the levels in the observation group were higher than those in the control group[(2.7±0.5)L/s vs(2.1±0.5)L/s,(2.4±0.6)L vs(1.9±0.5)L,(70.1± 2.6)％vs(60.4±1.3)％](all P＜0.05).CAT,SGRQ and PaCO2 in both groups after treatment were lower than those before treatment and the levels in the observation group were lower than those in the control group;PaO2 in both groups after treatment were higher than those before treatment and the level in the observation group was higher than that in the control group(all P＜0.05).Levels of IL-8 and PDE4 in both groups after treatment were lower than those before treatment and the levels in the observation group were lower than those in the control group(all P＜0.05).Conclusions Combined respiratory training with glycopyrronium bromide and formoterol is beneficial for enhancing respiratory function,improving blood oxygen supply and COPD condition,optimizing quality of life,and suppressing inflammatory factor levels in patients with stable COPD.