Clinical,endoscopic and pathological characteristics analysis of gastric hyperplastic polyps

Zhang Dongxue; Ding Shigang; Zhang Jing

doi:10.3760/j.issn.1673-4777.2024.03.015

Abstract：Objective To explore the clinical,endoscopic and pathological characteristics of gastric hyperplastic polyps(GHP).Methods The clinical,endoscopic,and pathological data of 4 010 patients diagnosed with GHP through gastroscopy and pathological examination at Peking University Third Hospital from January 1,2005 to December 31,2021 were retrospectively analyzed.Results The age of 4 010 GHP patients was(58± 14)years,of which 2 522 were female(62.9％),with a high incidence rate of 1 106 cases(27.6％)and 1 076 cases(26.8％)aged＞50-60 and＞60-70 years,respectively.There were 795 cases(19.8％)complicated with Helicobacter pylori infection;GHP was often solitary in 2 811 cases(70.1％),with the most common site being the gastric body,1 456 cases(36.3％),880 cases(21.9％)of the cardia,and 697 cases(17.4％)of the gastric antrum.Morphological classification was mainly Yamada type Ⅰ,2 401 cases(59.9％),and type Ⅱwas relatively common in 931 cases(23.2％).There were 2 278 patients(56.8％)with polyp diameters 0.5 cm;the incidence of GHP intestinal metaplasia was 5.5％(221/4 010),the incidence of dysplasia was 3.1％(124/4 010),and the incidence of cancer was 0.3％(12/4 010).In the GHP background gastric mucosa,chronic superficial gastritis accounted for 52.0％(2 083/4 010),and chronic atrophic gastritis accounted for 25.9％(1 040/4 010).Among them,755 cases of chronic atrophic gastritis accompanied by intestinal metaplasia accounted for 18.8％of the total,430 cases(10.7％)of autoimmune gastritis,333 cases(8.4％)of atypical hyperplasia,and 37 cases(0.9％)of gastric cancer.Conclusion Most GHP are solitary,distributed in the stomach body,and polyps have the possibility of dysplasia and canceration.For large polyps,endoscopic examination should be wary of the possibility of malignant change.