Study on the correlation of serum macrophage inflammatory protein-1α and matrix metalloproteinase-9 levels with thyroid nodules in patients with type 2 diabetes mellitus
Yang Xiaoyue
Song Honghong
Hu Shaozhen
Pan Ying
Bao Xiaoxue
Yan Wenying
Abstract：Objective To investigate the correlation of serum macrophage inflammatory protein-1α(MIP-1α)and matrix metalloproteinase-9(MMP-9)levels with thyroid nodules in patients with type 2 diabetes mellitus(T2DM).Methods Totally 154 patients with T2DM admitted to the Third Hospital of Hebei Medical University from October 2021 to March 2023 were retrospectively enrolled.Patients were divided into the thyroid nodule group(83 cases)and the non-thyroid nodule group(71 cases)according to whether they had thyroid nodules or not.Thyroid function,blood glucose,blood lipid,MIP-1α,MMP-9 and other indicators were compared between the two groups.Logistic regression model was used to analyze the factors affecting the occurrence of thyroid nodules in patients with T2DM.Pearson correlation test was used to analyze the correlation between the serum levels of MIP-1α,MMP-9 and other factors in patients with T2DM.Receiver operating characteristic curve was used to analyze the predictive value of the levels of serum MIP-1α and MMP-9 for the occurrence of thyroid nodules in patients with T2DM.Results The levels of thyroid stimulating hormone(TSH),total triplethyronine(TT3),total thyroxine(TT4),homeostasis model assessment of insulin resistance(HOMA-IR),homeostasis model assessment of islets β cell function,fasting blood glucose and fasting insulin in the thyroid nodule group were higher than those in the non-thyroid nodule group,and the insulin sensitivity index(ISI)in the thyroid nodule group was lower than that in the non-thyroid nodule group(all P＜0.05).The levels of serum MIP-1α and MMP-9 in the thyroid nodule group were higher than those in the non-thyroid nodule group[(29±5)ng/L vs(25±5)ng/L,(2.0±0.5)ng/L vs(1.4±0.5)ng/L](both P＜0.001).Logistic regression analysis showed that MIP-1α,MMP-9,TSH,TT3,TT4,fasting insulin,HOMA-IR and ISI were all risk factors for the occurrence of thyroid nodules in patients with T2 DM(all P＜0.05).Pearson correlation analysis showed that the levels of serum MIP-1α and MMP-9 were positively correlated in patients with T2DM(r=0.362,P＜0.001).The levels of serum MIP-1α and MMP-9 were positively correlated with fasting insulin,TSH,HOMA-IR,TT3 and TT4,and negatively correlated with ISI(all P＜0.001).The area under the curve of combined detection of MIP-1α and MMP-9 in predicting thyroid nodules in patients with T2DM was larger than that of MIP-1α or MMP-9 alone(both P＜0.05).Conclusion The levels of serum MIP-1α and MMP-9 are closely related to the occurrence of thyroid nodules in patients with T2DM,and they have important value in predicting thyroid nodules in patients with T2DM.
Keywords：Type 2 diabetes mellitusMacrophage inflammatory protein-1αMatrix metalloproteinase-9Thyroid nodules
Publication Date：2024-03-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 381-385 )