The effect of agatroban on early neurological function recovery in patients with small artery occlusive stroke
Zhu Jiang
Hu Shaofu
Chen Qihang
Dou Zhijie
Abstract：Objective To investigate the effect of agatroban on early neurological function recovery in patients with small artery occlusive stroke.Methods Totally 120 patients with ischemic stroke admitted to Department of Neurology,Affiliated Hospital of Chengde Medical University from June 2021 to December 2022 were enrolled.Patients were divided into agatrobangroup and dual antibody group using the random number table method,with 60 cases in each group.All patients were given basic treatment.On this basis,the agatroban group was given continuous intravenous infusion of agatroban injection,while the dual antibody group was given aspirin enteric coated tablets and clopidogrel oral treatment.The treatment period for both groups was 7 d.Clinical efficacy,neurological function,daily living ability,serum cytokine levels,hemorheology,and safety indicators were compared between the two groups.Results The total effective rate of the agatroban group was higher than that of the dual antibody group[81.7％(49/60)vs 65.0％(39/60)](P＜0.05).After treatment,the National Institutes of Health Stroke Scale score of agatroban group was lower than that of the dual antibody group,while the Activity of Daily Living Scale score was higher than that of the dual antibody group[(0.81±0.20)vs(1.34±0.37),(87±5)vs(78±4)](both P＜0.001).After treatment,the levels of interleukin-6,tumor necrosis factor-α,high-sensitivity C-reactive protein,whole blood viscosity shear rate,relative blood viscosity shear rate,plasma viscosity and fibrinogen in the two groups were all lower than those before treatment,and levels of the agatroban group were lower than those of the dual antibody group(all P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Agatroban is effective in the treatment of ischemic stroke caused by small artery occlusive stroke.It can promote the recovery of patients'early neurological function,improve the independence of daily life,reduce the level of inflammatory factors and improve hemorheology,and has good safety.
Keywords：StrokeIschemicSmall artery occlusion strokeAgatroban
Publication Date：2024-03-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 372-376 )