Association of novel coronavirus asymptomatic infection and mild infection with angina pectoris attack in patients with coronary atherosclerotic heart disease
Fan Chu
Lu Hui
Yan Hangyu
Yang Yonghong
Tao Juan
Liu Jielin
Li Dan
Dong Shutong
Li Xuepeng
Huang Ji
Abstract：Objective To investigate the association between novel coronavirus asymptomatic and mild infection and the occurrence of angina pectoris attack in patients with coronary atherosclerotic heart disease(CHD).Methods Totally 231 cases of CHD combined with novel coronavirus infection asymptomatic and mild infection admitted to Beijing Anzhen Hospital,Capital Medical University,from December 2022 to January 2023 were retrospectively collected.The patients were divided into control group(asymptomatic infection patients,115 cases)and observation group(mild infection,116 cases)according to the type of symptoms of novel coronavirus,and the clinical characteristics of the two groups were compared.Patients were followed-up for 1 month after the novel coronavirus infection,and the incidence of angina pectoris was compared between the two groups.The Cox regression model was used to analyze independent risk factors for angina pectoris attack.Results Compared to the control group,age of the observation group was older,body mass index,D-Dimer and hemoglobin levels were lower,and the proportion of chronic lung disease was higher(all P＜0.05).The risk of angina pectoris in the short term in the observation group was higher than that in the control group(hazard ratio:2.371,95％confidence interval:1.373-4.094,P=0.002).Multivariate Cox regression analysis showed that age(hazard ratio:1.065,95％confidence interval:1.026-1.106,P=0.001),number of coronary lesion branches(hazard ratio:1.777,95％confidence interval:1.297-2.435,P＜0.001),and type of novel coronavirus symptoms(hazard ratio:1.813,95％confidence interval:0.986-3.101,P=0.031),haemoglobin level(hazard ratio:0.980,95％confidence interval:0.963-0.997,P=0.024)were short-term independent risk factors for angina pectoris.Conclusions The risk of angina pectoris is higher in CHD patients with mild infection with novel coronavirus than those with asympto-matic infection,and the occurrence of angina pectoris is independently associated with patient age,type of novel coronavirus symptoms,number of coronary lesion branches,and haemoglobin level.
Keywords：Coronary atherosclerotic heart diseaseNovel coronavirus infectionAngina pectoris
Publication Date：2024-03-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 326-330 )