The relationship between body mass index,blood lipid indicators and Helicobacter pylori infection

Liu Xuexin; Chen Wenyan; Wang Xiaoxi

doi:10.3760/j.issn.1673-4777.2024.02.019

Abstract：Objective To explore the relationship between body mass index(BMI),blood lipid indicators and Helicobacter pylori(Hp)infection.Methods Totally 2 000 healthy individuals who underwent physical examinations in Hebei General Hospital from January to April 2023 were selected as the research subjects.All individuals underwent 13C urea breath test and were counted for Hp positivity,and they were divided into Hp positive group and Hp negative group.BMI and blood lipid indicators were compared between the two groups.The correlation of Hp positive with BMI and lipid indicators,and the risk factors of Hp positive were analyzed.Results Among the 2 000 healthy individuals undergoing physical examination,747 cases(37.4％,Hp positive group)were Hp positive,and 1 253 cases(62.6％,Hp negative group)were Hp negative.The rate of normal BMI in Hp positive group was lower than that in Hp negative group,and rates of overweight and obesity in Hp positive group were higher than those in Hp negative group(all P＜0.001).The rates of high-density lipoprotein cholesterol(HDL-C)decreased and low-density lipoprotein cholesterol(LDL-C),triacylglycerol and total cholesterol increased in Hp positive group were higher than those in Hp negative group(all P＜0.001).Pearson correlation analysis showed that Hp positive was positively correlated with BMI,LDL-C,triacylglycerol and total cholesterol(r=0.582,0.547,0.618,0.534,allP＜0.001),and was negatively correlated with HDL-C(r=-0.651,P＜0.001).Multivariate Logistic regression analysis showed that BMI≥24 kg/m2,HDL-C decreased and LDL-C,triacylglycerol and total cholesterol increased were independent risk factors for Hp positive.Conclusion Elevated BMI and dyslipidemia are closely related to Hp infection,and are independent risk factors for Hp infection.