Correlation of serum fetuin-B level and type 2 diabetes mellitus complicated with peripheral neuropathy

Liu Yajuan; Luo Xiaohong; Dong Li; Wang Fuhui; Wu Xiaofen; Xu Ruiyuan; Wei Honghong

doi:10.3760/j.issn.1673-4777.2024.02.016

Abstract：Objective To explore the correlation between serum fetuin-B level and type 2 diabetes mellitus(T2DM)complicated with diabetic peripheral neuropathy(DPN).Methods Totally 145 T2DM patients admitted to Department of Endocrinology,the 940th Hospital of Joint Logistics Support Force of the Chinese People's Liberation Army from January to October 2022 were included.According to whether to merge DPN,they were divided into simple T2DM group(79 cases)and T2DM combined with DPN group(66 cases).In addition,25 healthy volunteers from the physical examination center of the hospital were selected as the healthy control group.General information,glucose and lipid metabolism indicators,and biochemical related indicators of all subjects were collected.The serum fetuin-B levels of all subjects were detected using enzyme-linked immunosorbent assay and compared among groups.The Spearman correlation analysis method was used to analyze the correlation between serum fetuin-B level and other indicators.The binary Logistic regression analysis method was used to analyze the influencing factors of T2DM combined with DPN.The receiver operating characteristic curve was used to evaluate the predictive efficacy of fetuin-B in T2DM combined with DPN.Results The levels of fetuin-B in the T2DM combined with DPN group were significantly higher than those in the simple T2DM group and the healthy control group,and the level of fetuin-B in the simple T2DM group was higher than that in the healthy control group(all P＜0.05).The results of correlation analysis showed that fetuin-B was positively correlated with the course of diabetes mellitus(r=0.369,P＜0.001),fasting plasma glucose(r=0.307,P＜0.001),glycosylated serum protein(r=0.411,P＜0.001),glycosylated hemoglobin(r=0.366,P＜0.001),total cholesterol(r=0.366,P＜0.001),low-density lipoprotein cholesterol(r=0.161,P=0.036),and blood urea nitrogen(r=0.166,P=0.030);there was a significant negative correlation with fasting insulin(r=-0.309,P＜0.001),high-density lipoprotein cholesterol(r=-0.209,P=0.006),and estimated glomerular filtration rate(r=-0.274,P＜0.001).The Logistic regression analysis showed that high levels of fetuin-B were a risk factor for T2DM combined with DPN(P＜0.05).Serum fetuin-B has certain predictive value for T2DM combined with DPN,with an area under the receiver operating characteristic curve of 0.826(95％confidence interval:0.752-0.900,P=0.010).Conclusions Elevated level of serum fetuin-B is a risk factor for DPN in patients with T2DM.High fetuin-B levels are associated with the occurrence and development of DPN.