Effects of metformin combined with vitamin D on levels of serum insulin-like growth factor-1 and bone metabolic markers in patients with diabetes mellitus and osteoporosis
Dong Juan
Li Yuepeng
Zhang Renfei
Zhao Yuetao
Qiu Lei
Abstract：Objective To investigate the effect of metformin combined with vitamin D on levels of serum insulin-like growth factor-1(IGF-1)and bone metabolic markers in patients with diabetes mellitus and osteoporosis.Methods Totally 160 patients with type 2 diabetes mellitus(T2DM)and osteoporosis admitted to Beijing Hospital from March 2020 to March 2023 were enrolled.Patients were randomly divided into control group and observation group,with 80 cases in each group.The control group was treated with vitamin D combined with routine blood glucose control methods such as exercise intervention and diet control,and the observation group was treated with metformin on the basis of the control group.The levels of fasting plasma glucose(FPG),postprandial 2 h plasma glucose(2 hPG),glycated hemoglobin(HbA1c),serum calcium,serum phosphorus,osteocalcin,total n-terminal propeptide of type Ⅰ precollagen(T-P Ⅰ NP),IGF-1,high-sensitivity C-reactive protein(hs-CRP)and vitamin D3 before and after treatment as well as total effective rate were compared between the two groups.Results After treatment,levels of FPG,2 hPG,HbA1c,serum phosphorus and hs-CRP in both groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group(all P＜0.05);serum levels of calcium,osteocalcin,T-P Ⅰ NP,bone mineral density,IGF-1 and vitamin D3 in both groups were higher than those before treatment,and the levels in the observation group were higher than those in the control group[(2.82±0.20)mmol/L vs(2.40±0.15)mmol/L,(19.9±2.4)ng/L vs(13.6±2.1)ng/L,(48±4)μg/L vs(37±4)μg/L,(0.98±0.16)g/cm2 vs(0.78±0.15)g/cm2,(206±35)μg/L vs(137± 25)μg/L,(37±3)μg/L vs(29±3)μg/L](all P＜0.05).The total effective in the observation group was higher than that in the control group(P＜0.001).Conclusions Metformin combined with vitamin D is effective in the treatment of T2 DM with osteoporosis,which can control plasma glucose level better,raise serum IGF-1 level,and improve bone metabolism.
Keywords：Diabetes mellitusMetforminVitamin DOsteoporosisInsulin-like growth factor-1
Publication Date：2024-02-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 226-230 )