Study on the correlation of matrix metalloproteinase 9,matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 levels with the severity of tuberculous meningitis and their prognostic predictive value
Wang Qi
Yuan Tian
Fang Zhe
Chen Hongmei
Abstract：Objective To explore the correlation of levels of matrix metalloproteinase 9(MMP-9),MMP-9/tissue inhibitor of metalloproteinases 1(TIMP-1)with the severity of tuberculous meningitis,as well as the predictive value of prognosis.Methods Totally 72 patients with tuberculous meningitis admitted to Hunan Chest Hospital from January 2021 to February 2023 were selected as the observation group,and 52 patients with non tumor and non infectious headache hospitalized at the same time were selected as the control group.According to the improved Medical Research Council staging criteria for tuberculous meningitis,patients in observation group were divided into Phase Ⅰ,Ⅱ,and Ⅲgroups,and the levels of MMP-9 and MMP-9/TIMP-1 in each group were compared.According to the prognosis,patients of observation group were divided into good prognosis group and poor prognosis group,and the levels of MMP-9 and MMP-9/TIMP-1 were compared between the two groups.The receiver operating characteristic(ROC)curve method was used to evaluate the prognostic evaluation efficacy of each indicator for tuberculous meningitis.Results The levels of MMP-9 and MMP-9/TIMP-1 in the observation group were higher than those in the control group[(96±21)μg/L vs(50±12)μg/L,(1.21±0.33)vs(0.67± 0.15)](both P＜0.05),but there was no statistically significant difference in TIMP-1 between the two groups(P＞0.05).The levels of MMP-9 and MMP-9/TIMP-1 in patients with tuberculous meningitis of different severity levels showed statistically significant differences,and both showed a trend of stage Ⅰ＜stage Ⅱ＜stage Ⅲ(all P＜0.05).There was no statistically significant difference in TIMP-1 levels among patients with tuberculosis meningitis of different severity levels(P＞0.05).The correlation analysis results showed a positive correlation between the severity of tuberculous meningitis and MMP-9 and MMP-9/TIMP-1(r=0.861,P=0.012;r=0.731,P=0.008).The severity of tuberculous meningitis was not significantly correlated with TIMP-1(r=0.220,P=0.063).The levels of MMP-9 and MMP-9/TIMP-1 in poor prognosis group were higher than those in good prognosis group(both P＜0.05),and there was no statistically significant difference in TIMP-1 levels between the two groups(P＞0.05).The ROC analysis showed that the cutoff values of MMP-9 and MMP-9/TIMP-1 for predicting poor prognosis in patients with tuberculous meningitis were 112.04 μg/L and 1.41,and the area under the curve was 0.803 and 0.905,respectively(both P＜0.05).Conclusions The levels of MMP-9 and MMP-9/TIMP-1 in cerebrospinal fluid of patients with tuberculous meningitis were significantly increased,and the levels of MMP-9 and MMP-9/TIMP-1 were positively correlated with the severity of tuberculous meningitis,which can be used to predict patient prognosis.
Keywords：Tuberculous meningitisMatrix metalloproteinase 9Tissue inhibitor of metalloproteinases 1Severity of conditionPrognostic prediction
Publication Date：2024-02-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 207-211 )