Effect of sodium-glucose cotransporter 2 inhibitor on clinical parameters and prognosis of patients with acute myocardial infarction complicated with type 2 diabetes mellitus
Wang Kai
Wang Lin
Hu Guangquan
Fan Tingting
He Fei
Cheng Cheng
Abstract：Objective To observe the effect of sodium-glucose cotransporter 2 inhibitor(SGLT-2i)on clinical parameters and prognosis of patients with acute myocardial infarction(AMI)and type 2 diabetes mellitus(T2DM).Methods Retrospective selection of 180 patients with AMI and T2DM diagnosed at Chest Pain Center,the Second Hospital of Anhui Medical University from January 2020 to June 2022 were enrolled.According to the selection of hypoglycemic regimens after admission,patients were divided into control group(79 cases,treated with sulfonylureas,α-glycossidase inhibitors,metformin etc.)and observation group(101 cases,administered with dapagliflozin or empagliflozin).All patients were followed-up regularly after discharge,and the clinical indicators and major adverse cardiovascular events(MACE)were compared between the two groups.Results All patients were followed-up for 6-12 months,the white blood cell count in the observation group was lower than that in the control group[(7.4±1.6)×109/L vs(8.7±1.6)× 109/L],and the improvement of left ventricular end diastolic diameter was better than that in the control group[(-0.527±1.462)mm vs(1.359±2.111)mm](all P＜0.05).The incidence of MACE in the observation group was lower than that in the control group[5.4％(2/37)vs 25.0％(8/32)](P=0.020).Conclusion Compared with other hypoglycemic agents,SGLT-2i can improve cardiac function and prognosis in patients with AMI and T2DM within 12 months,while it can reduce the systemic inflammatory reaction in such patients.
Keywords：Acute myocardial infarctionType 2 diabetes mellitusSodium-glucose cotransporter 2 inhibitorMajor adverse cardiovascular events
Publication Date：2024-02-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 171-175 )