Analysis of clinical characteristics and risk factors of patients with acquired solitary kidney
Zhou Jing
Wang Huiming
Abstract：Objective To analyze the clinical characteristics and risk factors of patients with acquired solitary kidney(ASK).Methods The clinical data of 336 ASK patients admitted to Renmin Hospital of Wuhan University from January 2011 to November 2022 were retrospectively collected.Kaplan-Meier survival curve was used to compare the cumulative incidence of postoperative end-stage renal disease in different groups of ASK patients.Univariate and multivariate Logistic regression were used to analyze the risk factors for the progression of postoperative renal dysfunction in patients with ASK.Results There were 147 cases(43.8％)of hypertension,34 cases(10.1％)of coronary artery disease,37 cases(11.0％)of cardiovascular and cerebrovascular events,53 cases(15.7％)of diabetes,8 cases(2.4％)of liver cirrhosis,105 cases(31.3％)of hyperlipidemia,137 cases(40.8％)of anemia,127 cases(37.8％)with hyperuricemia,239 cases(71.1％)with hematuria,68 cases(20.2％)with contralateral urinary tract surgery history and 149 cases(44.3％)with proteinuria.Univariate Logistic regression analysis showed that the duration of nephrectomy,age of nephrectomy,preoperative hypertension,hyperuricemia,proteinuria,history of contralateral urinary tract surgery,anemia,and non-laparoscopic were associated with postoperative estimated glomerular filtration rate＜60 ml/(min·1.73 m2)(all P＜0.05).Multivariate Logistic regression analysis showed that the duration of nephrectomy ≥5 years,age of nephrectomy ≥45 years,hypertension,hyperuricemia,urinary protein trace or above,history of contralateral urinary tract surgery and anemia were independent risk factors for postoperative estimated glomerular filtration rate＜60 ml/(min·1.73 m2).Conclusion The proportion of ASK patients with clinical etiology is high,such as hypertension and diabetes.Among them,patients with kidney resection time ≥ 5 years,kidney resection age ≥ 45 years,hypertension,hyperuricemia,urinary protein trace or above,history of contralateral urinary tract surgery,and anemia are more likely to have postoperative renal function progression.
Keywords：Acquired solitary kidneyUnilateral nephrectomyEnd-stage renal disease
Publication Date：2024-01-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 74-78 )