Effects of liraglutide combined with atorvastatin on blood glucose,adipokines and intestinal flora in obese patients with type 2 diabetes mellitus
Li Min
Gao Ruichao
Zhang Zhijia
Liu Xuan
Tong Yuhuan
Tan Zenghuan
Yang Li
Abstract：Objective To investigate the effect of liraglutide combined with atorvastatin on blood glucose,adipokines and intestinal flora in obese patients with type 2 diabetes mellitus(T2 DM).Methods The computerized random number table method was applied to divide 132 obese T2DM patients admitted to Handan Central Hospital,Hebei Province from January 2019 to January 2021 into the observation group and the control group,with 66 cases in each group.Both groups were given conventional treatment,based on which the control group was given atorvastatin and the observation group was given atorvastatin combined with liraglutide.The duration of treatment was 6 months in both groups.The fasting blood glucose(FBG),glycated haemoglobin(HbA1c),2 h postprandial blood glucose(2 hPG),body mass index,waist circumference,waist-to-hip ratio,adipokines[resistin,leptin,visfatin,adiponectin and fatinfluencing protein-1(Nesfatin-1)],intestinal flora and occurrence of adverse reactions were compared between two groups.Results After treatment,FBG,2 hPG,HbA1c,body mass index,waist circum-ference,waist-to-hip ratio,resistin,leptin,and visfatin in the observation group were lower than those in the control group,while adiponectin and Nesfatin-1 were higher than those in the control group(all P＜0.05).After treatment,Enterobacteriaceae and Enterococcus in the observation group were lower than those before treatment and in the control group,while Yeast,Bifidobacteria and Lactobacillus were higher than those before treatment and in the control group(all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group[10.6％(7/66)vs 6.1％(4/66)](P=0.345).Conclusion Liraglutide combined with atorvastatin in the treatment of obese T2DM can improve glucose metabolism,adipokines and intestinal flora,reduce body mass index,waist circumference,waist-to-hip ratio,and is safe and reliable.
Keywords：Type 2 diabetes mellitusObesityLiraglutideAtorvastatinBlood glucoseAdipokinesIntestinal flora
Publication Date：2024-01-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 55-59 )