Association of body mass index and serum complement C1q in patients with type 2 diabetes mellitus

Liang Yuanfang; Yan Ni; Zhang Duanni; Hui Rong; Li Xiaoyan

doi:10.3760/j.issn.1673-4777.2024.01.011

Abstract：Objective To investigate the relationship between body mass index(BMI)and serum complement C1q in patients with type 2 diabetes mellitus(T2DM).Methods The basic information,anthropo-metric parameters and biochemical parameters of 119 patients with T2DM admitted to Department of Endocrinology,Shaanxi Provincial People's Hospital from January to December 2019 were collected.According to BMI level,subjects were divided into control group(BMI＜24 kg/m2,56 cases)and observation group(BMI ≥24 kg/m2,63 cases).The differences of serum complement C1q and other indexes between the two groups were compared.The correlation between BMI and clinical indexes was analyzed.Receiver operating characteristic curve was used to analyze the value of serum complement C1q levels in predicting BMI ≥24 kg/m2 in T2DM patients.Results The level of C1q in observation group was significantly higher than that in control group[(185±41)mg/L vs(171± 33)mg/L](P＜0.05).BMI was positively correlated with height,body mass,waist circumference,hip circum-ference,waist-to-hip ratio,y-glutamyl transpeptidase,cholinesterase,albumin,triacylglycerol,blood phosphorus,blood uric acid,and complement C1q,and was negatively correlated with age,blood urea nitrogen and blood chlorine(P＜0.05 or P＜0.01).The optimal cutoff value for predicting BMI ≥24 kg/m2 in T2DM patients with serum complement C1q was 183.8 mg/L,the area under the curve was 0.600(95％confidence interval:0.498-0.701),the sensitivity was 67.9％,and the specificity was 52.4％.Conclusion There is a positive correlation between BMI and serum complement C1q level in T2DM patients,suggesting that serum C1q may be involved in the occurrence and development of BMI increase in T2DM patients.