The relationship between serum vascular adhesion molecule 1,trefoil factor 3 levels and chemotherapy efficacy and prognosis in advanced non-small cell lung cancer

Wang Xinwei; Fang Ying; Wang Xin

doi:10.3760/j.issn.1673-4777.2024.01.009

Abstract：Objective To investigate the relationship between vascular adhesion molecule 1(VCAM1),trefoil factor 3(TFF3)levels and chemotherapy efficacy and prognosis in patients with advanced non-small cell lung cancer(NSCLC).Methods Totally 112 advanced NSCLC patients who received chemotherapy treatment in Jiangsu Cancer Hospital from February 2019 to February 2021 were selected as the observation group.Another 70 healthy individuals who underwent physical examinations during the same period were selected as the control group.Serum VCAM1 and TFF3 levels of subjects were detected.According to the effect after chemotherapy,patients in the observation group were divided into the chemotherapy effective group and the chemotherapy ineffective group.Follow-up for 1 year,the differences in survival prognosis among patients with advanced NSCLC with different levels of serum VCAM1 and TFF3 expression were compared.Multivariate Cox regression analysis was used to analyze factors affecting the survival prognosis of advanced NSCLC patients.Results The serum levels of VCAM1 and TFF3 in the observation group were higher than those in the control group[(227±24)μg/L vs(79±13)μg/L,(1.59±0.37)μg/L vs(0.47±0.14)pμg/L](both P＜0.001).The serum levels of VCAM1 and TFF3 in advanced NSCLC patients were related to tumor differentiation and TNM staging(all P＜0.05).The serum levels of VCAM1 and TFF3 in the chemotherapy ineffective group were higher than those in the chemotherapy effective group(both P＜0.001).The overall 1-year survival rate was 26.9％(14/52)in the VCAM1 high expression group,and 55.0％(33/60)in the VCAM1 low expression group,and the difference was statistically significant(Log-rank x2=12.181,P＜0.001).The overall 1-year survival rate was 27.8％(15/54)in the TFF3 high expression group,and 55.2％(32/58)in the TFF3 low expression group,and the difference was statistically significant(Log-rank x2=14.146,P＜0.001).Multivariate Cox regression analysis showed that low tumor differentiation,TNM staging Ⅳ,high expression of VCAM1,and high expression of TFF3 were independent risk factors affecting the poor survival prognosis of advanced NSCLC patients.Conclusion Elevated serum VCAM1 and TFF3 levels in patients with advanced NSCLC are associated with adverse clinical pathological features and chemotherapy efficacy.