Efficacy of omeprazole combined with FOLFOX6 chemotherapy on postoperative colon cancer patients

Huang Yang

doi:10.3760/j.issn.1673-4777.2023.12.017

Abstract：Objective To investigate the effects of omeprazole combined with oxaliplatin+folinic acid+5-fluorouracil(FOLFOX6)chemotherapy regimen on postoperative colon cancer patients.Methods Totally 80 patients with colon cancer admitted to the Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from July 2017 to August 2019 were collected.They were divided into the control group and the observation group according to the treatment plan,with 40 cases in each group.The control group was treated with FOLFOX6 chemotherapy plan,and the observation group was treated with omeprazole on the basis of FOLFOX6 chemotherapy plan.After treatment,patients were followed-up for 3 years.The objective response rate(ORR)after 6-8 courses of chemotherapy,the expression of Vacuolar-type ATPase(V-ATPase)protein,the 1,2 and 3-year progression free survival rate,the 1,2 and 3-year progression free survival rate of patients with different status of V-ATPase protein expression and occurrence of adverse reactions were compared between the two groups.Results The ORR of the observation group was higher than that of the control group[65.0％(26/40)vs 37.5％(15/40)](P=0.014).There was no statistically significant difference in the positive rate of V-ATPase protein between the two groups(P＞0.05).The observation group had significantly higher progression free survival rates at the 1,2 and 3-year after surgery compared to the control group[82.5％(33/40)vs 57.5％(23/40),70.0％(28/40)vs 45.0％(18/40),47.5％(19/40)vs 25.0％(10/40)](all P＜0.05).In the control group,there was no statistically significant difference in the 1,2,3-year progression free survival rate between V-ATPase protein positive individuals and V-ATPase protein negative individuals(all P＞0.05);however,in the observation group,the 1,2 and 3-year progression free survival rates of V-ATPase protein positive individuals were higher than those of V-ATPase protein negative individuals(all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(all P＞0.05).Conclusion Omeprazole combined with FOLFOX6 chemotherapy scheme can not only improve the ORR of colon cancer patients after surgery,but also improve the effect of colon cancer patients with positive expression of V-ATPase protein for 1-3 years.