Effects of albumin-bound paclitaxel combined with platinum-based chemotherapy and intensity-modulated radiotherapy on immune function and serum tumor markers in patients with advanced esophageal cancer

Fang Yuan; Meng Wei; Liu Lan; Li Peng; Shi Jing

doi:10.3760/j.issn.1673-4777.2023.12.015

Abstract：Objective To investigate the effects of albumin-bound paclitaxel combined with platinum-based chemotherapy and intensity-modulated radiotherapy on immune function and tumor markers in patients with advanced esophageal cancer.Methods Totally 62 patients with advanced esophageal cancer admitted to the First Affiliated Hospital of Hebei North University from March 2020 to December 2021 were enrolled.According to the simple random number table method,patients were divided into observation group(31 cases)and control group(31 cases).The control group received platinum-based chemotherapy combined with intensity-modulated radio-therapy,and the observation group received albumin-bound paclitaxel on the basis of the control group.Serum levels of carcinoembryonic antigen(CEA),cytokeratin 19 fragment(CYFRA21-1),squamous cell cancer-antigen(SCC-Ag),and the distribution of T lymphocytes before and after treatment in the two groups were compared.Karnofsky performance status(KPS)score,degree of myelosuppression and curative rate of patients were recorded.Results After treatment,serum levels of CEA,CYFRA21-1 and SCC-Ag in both groups were lower than those before treatment,and the observation group was lower than the control group[(1.6±0.4)mg/L vs(2.1± 0.4)mg/L,(2.2±0.5)μg/L vs(2.7±0.6)µg/L,(0.79±0.25)μg/L vs(0.94±0.27)μg/L];CD3+,CD4+and CD4+/CD8+ratio in the observation group after treatment were lower than those before treatment and the control group,and CD8+was higher than that before treatment and the control group(all P＜0.05).After treatment,KPS score in the observation group was significantly higher than that in the control group(P＜0.001).The myelosup-pression score in the observation group was lower than that in the control group,and the tumor control rate in the observation group was higher than that in the control group(both P＜0.05).Conclusions Albumin-bound paclitaxel combined with platinum-based chemotherapy and intensity-modulated radiotherapy have good effect on tumor control in patients with advanced esophageal cancer,which can significantly reduce the level of tumor markers,improve the immune function of patients,improve the quality of life of patients,and reduce the toxicity caused by radiotherapy and chemotherapy.