Protective effect of ambroxol hydrochloride combined with levodopa and benserazide on motor function and autonomic nerves in patients with early Parkinson's disease
Jiang Ying
Liang Jianfen
Lei Yilu
Mao Danfeng
Tang Xuli
Wang Linhai
Zhang Xingbo
Abstract：Objective To explore the protective effect of ambroxol hydrochloride combined with levodopa and benserazide on motor function and autonomic nerves in patients with early Parkinson's disease.Methods Totally 75 patients with early Parkinson's disease admitted to the First Affiliated Hospital of Guangxi University of Chinese Medicine from November 2020 to April 2022 were selected.Patients were divided into observation group(38 cases)and control group(37 cases)by the random number table method.The control group was treated with levodopa and benserazide orally,and the observation group was treated with ambroxol hydrochloride oral solution based on the control group.The scores of modified Webster scale,Unified Parkinson's Disease Rating Scale(UPDRS)and Parkinson's Disease Autonomic Symptom Scale(SPOCA-AUT)scores were compared between the two groups before and after treatment.Patients in the observation and control groups were matched 1∶1 by the propensity score matching(PSM)extended beam.Results Following PSM,there were 36 cases in each observation group and control group.After 3 months of treatment,the score of modified Webster scale in both groups decreased,and the score in the observation group was lower than that in the control group[(8.4±1.4)vs(15.3±1.4)](all P＜0.001).The total response rate in the observation group was higher than that in the control group[91.7％(33/36)vs 69.4％(25/36)](P=0.038).After 1,2 and 3 months of treatment,all item scores of UPDRS in both groups trended downward,and the scores in the observation group 2 and 3 months after treatment were lower than those in the control group(all P＜0.05).After 3 months of treatment,all item scores of SPOCA-AUT in both groups were lower than those before treatment,and the scores of urinary symptoms,thermoregulatory symptoms,sexual function symptoms in the observation group were lower than those in the control group(all P＜0.05).Conclusion Ambroxol hydrochloride combined with levodopa and benserazide can improve the motor function of early elderly patients with Parkinson's disease and play the role of autonomic nerve protection.
Keywords：Parkinson's diseaseAmbroxol hydrochlorideLevodopa and benserazideAutonomic nervous function
Publication Date：2023-12-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1807-1811 )