Predictive value of peripheral blood microRNA-210 level for secondary pulmonary hypertension in patients with chronic obstructive pulmonary disease

Chen Sirui; Cai Qian; Zhu Yingqun; Li Zhe; Liu Jinhua

doi:10.3760/j.issn.1673-4777.2023.12.008

Abstract：Objective To explore the predictive value of peripheral blood microRNA(miR)-210 level for secondary pulmonary hypertension(PAH)in patients with chronic obstructive pulmonary disease(COPD).Methods From January 2019 to December 2020,100 patients with COPD treated in the Third Hospital of Changsha,Hunan Province were selected as the COPD group,including 43 patients with secondary PAH(PAH subgroup)and 57 patients with normal pulmonary artery pressure(non PAH subgroup).In addition,42 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.The clinical data such as miR-210 level(among 3 groups),blood gas analysis and lung function(between COPD subgroups)were compared.Pearson correlation analysis was used to analyze the correlation between peripheral blood miR-210 level and pulmonary artery systolic pressure.The predictive value of miR-210 for secondary PAH in COPD was analyzed by receiver operating characteristic curve.Results The serum miR-210 level in the COPD group was lower than that in the control group[(13±5)vs(30±6)](t=15.890,P＜0.001).The miR-210,arterial partial pressure of oxygen,forced expiratory volume at the first second,ratio of forced expiratory volume in the first second to forced vital capacity in the PAH subgroup were lower than those in the non PAH subgroup(all P＜0.05).Pearson correlation analysis showed that the miR-210 level of peripheral blood was negatively correlated with pulmonary artery systolic pressure in PAH subgroup(P＜0.05).The receiver operating characteristic curve analysis results showed that the area under the curve for predicting secondary PAH in COPD by the miR-210 level of peripheral blood was 0.881,with specificity and sensitivity of 76.2％and 86.2％,respectively.The Youden index was 0.61,and the cutoff value for prediction was 7.5.Conclusion The expression level of peripheral blood miR-210 has predictive value for secondary PAH in patients with COPD.