Correlation of cystatin C,homocysteine and apolipoprotein A-1 levels with heart failure in patients with acute myocardial infarction
Tian Xue
Xing Xinyue
Li Hong
Abstract：Objective To analyze the correlation of cystatin C,homocysteine and apolipoprotein A-1 with heart failure in patients with acute myocardial infarction(AMI).Methods Data of 507 patients with AMI admitted to Beijing Anzhen Hospital,Capital Medical University from January 2020 to December 2021 were retrospectively analyzed.According to the presence or absence of heart failure,the patients were divided into heart failure group(285 cases)and non-heart failure group(222 cases).The clinical data of the two groups were compared,and the risk factors of heart failure in patients with AMI were analyzed.The predictive value of cystatin C,homocysteine and apolipoprotein A-1 in AMI complicated with heart failure was analyzed.Results The male ratio,age and the levels of serum creatinine,troponin Ⅰ,N-terminal pro-brain natriuretic peptide(NT-proBNP),cystatin C,homocysteine in the heart failure group were higher than those in the control group;and the proportion of emergency percutaneous coronary intervent ion(PCI)treatment,the levels of albumin,apolipoprotein A-1 and left ventricular ejection fraction(LVEF)were lower than those in the control group(all P＜0.05).Multivariate Logistic regression analysis showed that increase of age[odds ratio(OR)=6.524],no emergency PCI(OR=2.473),decrease of LVEF(OR=6.561),increase of NT-proBNP(OR=1.385),increase of cystatin C(OR=3.057),increase of homocysteine(OR=1.147)and decrease of apolipoprotein A-1(OR=1.142)were independent risk factors for heart failure in patients with AMI(all P＜0.05).Receiver operating characteristic curve analysis results showed that the area under the curve of cystatin C,homocysteine and apolipoprotein A-1 combined in predicting heart failure in patients with AMI was 0.819,and the sensitivity and the specificity were 72.4％and 80.5％,respectively.Conclusions Cystatin C,homocysteine and apolipoprotein A-1 are independent risk factors for heart failure in patients with AMI.The combination of the three has a good clinical value in predicting heart failure in patients with AMI.
Keywords：Acute myocardial infarctionCystatin CHomocysteineApolipoprotein A-1Heart failure
Publication Date：2023-12-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1774-1778 )