Study on the risk factors of morbidity and mortality in patients with acute coronary syndrome

Li Yanyan; Xu Baoli

doi:10.3760/j.issn.1673-4777.2023.12.003

Abstract：Objective To investigate the risk factors of morbidity and mortality in patients with acute coronary syndrome(ACS).Methods A total of 180 patients with coronary atherosclerotic heart disease admitted to the Department of General Diagnosis and Treatment,the First Affiliated Hospital of Air Force Medical University from January 2020 to December 2022 were selected as the research subjects.According to the different conditions,they were divided into acute group(66 cases,ACS patients)and non-acute group(114 cases,non-ACS patients).The clinical data of the two groups were compared,and the multivariate Logistic regression model was used to analyze the influencing factors of the morbidity and mortality of ACS patients.Results The age,triglyceride level and the proportion of hypertension,diabetes,hyperlipidemia,smoking history,and drinking history in the acute group were greater/higher than those in the non-acute group(all P＜0.05).Multivariate Logistic regression analysis showed that age,hypertension,diabetes,hyperlipidemia,smoking history,drinking history,and triglyceride were risk factors of ACS(odds ratio=3.586,4.225,4.204,3.728,4.003,5.349,3.391,95％confidence interval:1.498-5.674,1.987-6.463,1.979-6.429,1.669-5.787,1.897-6.109,2.846-7.852,1.388-5.394,all P＜0.05).In ACS patients,age,time from onset to visit,the proportions of patients with Killip grade≥Ⅲ,hypertension,diabetes,hyperlipidemia,smoking history,drinking history,three-vessel disease,and diffuse lesions in death group were greater/longer/higher than those in survival group,and the proportion of collateral circulation establishment in death group was lower than that in survival group(all P＜0.05).Multivariate Logistic regression analysis showed that age,time from onset to visit,Killip grade ≥Ⅲ,hypertension,diabetes,hyperlipidemia,smoking history,drinking history,three-vessel disease,and diffuse lesions were risk factors for death of ACS patients,and collateral circulation was a protective factor for mortality in ACS patients(all P＜0.05).Conclusions There are many influencing factors for the morbidity and mortality of ACS.Patients with related high-risk factors should pay attention to the prevention and treatment of ACS,be admitted to the hospital as soon as possible to receive effective treatment,and control the development process of the disease to reduce the number of ACS deaths.