Effect of Qingfei Xiaoyan pills combined with western medicine on community-acquired pneumonia, immune function and inflammatory factors
Li Rongxiang
Shi Huifang
Qi Dayun
Zhou Haiping
Abstract：Objective To investigate the curative effect of Qingfei Xiaoyan pills combined with western medicine on community-acquired pneumonia ( CAP ) and the influence on immune function and inflammatory factors. Methods Totally 123 patients with CAP admitted to People's Hospital of Wanning, Hainan Province from April 2016 to November 2018 were randomly divided into control group(n=61) and observation group(n=62). The control group was treated with azithromycin and ceftriaxone on the basis of routine therapy;the observation group was treated with Qingfei Xiaoyan pills on the basis of control group. Clinical efficacy, immune function indexes, inflammatory factors and adverse reactions were analyzed. Results The total effective rate in observation group was 87. 1％( 54/62 ) , which was significantly higher than 70. 5％( 43/61 ) in control group ( P=0. 024 ) . After treatment, serum levels of CD4+, CD4+ /CD8+, immunoglobulin A and immunoglobulin M significantly increased in both groups and the indexes in observation group were significantly higher than those in control group [(46 ± 4)％ vs (38 ± 3)％, (1. 87 ± 0. 39) vs (1. 35 ± 0. 24), (3. 4 ± 0. 6)g/L vs (3. 0 ± 0. 6)g/L, (1. 75 ± 0. 31)g/L vs (1. 31 ± 0. 27) g/L]; serum level of CD8+ significantly decreased and it was lower in observation group than that in control group[(24 ± 4)％ vs (28 ± 5)％](all P<0. 05). Serum levels of interleukin-6, tumor necrosis factor-α and C-reactive protein significantly decreased after treatment in both groups; the levels in observation group were significantly lower than those in control group [ ( 27 ± 4 ) ng/L vs ( 38 ± 4 ) ng/L, ( 38 ± 5)ng/L vs (49 ±8)ng/L, (17.4 ±2.3)mg/L vs (28.8 ±4.3)mg/L](all P <0.05). Disappearing time of fever, cough, expectoration and lung moist rales in observation group were significantly shorter than those in control group[(2. 5 ± 0. 3)d vs (3. 6 ± 0. 3) d, (7. 7 ± 0. 8) d vs (9. 8 ± 0. 5) d, (7. 4 ± 0. 6) d vs (9. 5 ± 0. 7) d, (7.1±0.5)dvs(8.8±0.5)d](allP <0.05). Therewasnosignificantdifferenceinincidenceofadverse reactions between groups(P = 0.598). Conclusions Qingfei Xiaoyan pills combined with western medicine treating CAP can effectively improve immune function and reduce inflammatory factors without increasing adverse reactions.
Keywords：Community-acquired pneumoniaQingfei Xiaoyan pillsAzithromycinCeftriaxoneImmune functionInflammatory factors
Publication Date：2020-04-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 555-559 )