Effect of metoprolol combined with trimetazidine on chronic heart failure

Hu Qing; Wang Yong; Cao Hongtao; Zhou Xiaoying; Gao Jiangyan; Liu Chao

doi:10.3760/j.issn.1673-4777.2020.04.009

Abstract：Objective To explore the effect of metoprolol combined with trimetazidine on myocardial remodeling, serum levels of N-terminal pro-brain natriuretic peptid(NT-proBNP) and hypersensitive C-reactive protein(hs-CRP) in patients with chronic heart failure. Methods A total of 100 patients with chronic heart failure admitted to Hebei Chest Hospital from December 2016 to December 2018 were randomly divided into obser-vation group and control group, with 50 cases in each group. The control group took metoprolol and the observation group took metoprolol plus trimetazidine on the basis of routine treatment. Clinical efficacy, serum NT-proBNP and hs-CRP levels, myocardial remodeling, quality of life and adverse reactions were analyzed. Results Total clinical effective rate in observation group was significantly higher than that in control group[92. 0％(46/50) vs 76. 0％(38/50)](χ2 =4. 714, P=0. 030). After treatment, levels of serum NT-proBNP and hs-CRP, left ventricular end-systolic dimension, left ventricular end-diastolic dimension, quality of life score significantly decreased compared with those before treatment; the indexes in observation group were significantly lower than those in control group[(458 ± 80)ng/L vs (873 ± 110)ng/L, (10. 5 ± 2. 9)mg/L vs (14. 4 ± 3. 6)mg/L, (36 ± 4)mm vs (41 ± 4)mm, (49 ± 4)mm vs (56 ± 4)mm, (41 ± 5) vs (49 ± 6)];left ventricular ejection fraction significantly increased after treatment and it was higher in observation group than that in control group [ ( 53 ± 5 )％ vs ( 47 ± 5)％](all P<0. 05). There was no significant difference in the incidence of adverse reactions between groups (χ2 =0.121, P=0.728). Conclusion Metoprolol combined with trimetazidine treating chronic heart failure can effectively reduce serum NT-proBNP and hs-CRP, promote myocardial remodeling and improve quality of life;the adverse reactions are tolerable.