Relation between small dense low-density lipoprotein and prognosis of acute myocardial infarction patients after percutaneous coronary intervention
Ma Lei
Huang Ji
Wu Xiangyu
Sun Junping
Hao Zhongling
Li Zhizhong
Abstract：Objective To investigate the correlation between small dense low-density lipoprotein(sdLDL)and prognosis in patients with acute myocardial infarction(AMI) after percutaneous coronary intervention(PCI). Methods A total of 353 patients with AMI who had PCI in Beijing Anzhen Hospital, Capital Medical University were enrolled from January to August 2018. Clinical indicators and blood lipid biochemical indexes were collected. All patients were followed up for at least 1 year to observe the occurrence of major adverse cardiovascular events (MACE). Influencing factors of sdLDL and risk factors affecting the prognosis of AMI were analyzed. Results There were 71 cases(20. 1％) of MACE occurring during follow-up, including 4 cases of all-cause death, 58 cases of recurrent angina, 8 cases of target revascularization and 1 case of malignant arrhythmia. Analysis showed that sdLDL was associated with triacylglycerol ( r =0. 509 ) , total cholesterol ( r =0. 812 ) and body mass index ( r =0. 132). Multivariate Cox regression analysis suggested that sdLDL ( hazard ratio = 1. 900, 95％ confidence interval:1. 067-3. 383), lipoprotein A(hazard ratio=2. 825, 95％ confidence interval:1. 441-5. 540) and uric acid(hazard ratio=1. 003, 95％ confidence interval:1. 000-1. 005) were independent risk factors of MACE(all P<0. 05). Kaplan-Meier survival analysis found that patients with sdLDL≥0. 78 mmol/L had poor prognosis at 1 year follow-up(Log-Rank = 4.463, P = 0.035). Conclusion SdLDL is a risk factor of MACE after PCI treating AMI.
Keywords：Acute myocardial infarctionSmall dense low-density lipoproteinPercutaneous coronaryinterventionPrognosis
Publication Date：2020-04-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 504-507 )