Early diagnosis value of heart-type fatty acid binding protein, red blood cell distribution width and cardiac troponin T combined detection for non-ST-segment elevation acute myocardial infarction
Deng Fengzhu
Li Chunfu
Fu Haiyan
Li Tianfa
Abstract：Objective To analyze the early diagnostic value of combined detection of heart-type fatty acid binding protein(H-FABP), red blood cell volume distribution(RDW) and cardiac troponin T(cTnT) in non-ST-segment elevation acute myocardial infarction(NSTEMI). Methods From August 2016 to August 2019, 45 NSTEMI patients ( NSTEMI group) , 41 non-NSTEMI patients( non-NSTEMI group, 22 cases of non cardiogenic chest pain and 19 cases of angina pectoris) and 43 healthy volunteers( control group) were enrolled at Hainan West Central Hospital. According to Gensini score, NSTEMI patients were divided into mild group, moderate group and severe group. Levels of H-FABP, RDW and cTnT were detected. Values of H-FABP, RDW and cTnT in early diagnosis of NSTEMI were analyzed by receiver operating characteristic(ROC) curve. Results Levels of H-FABP, RDW and cTnT in NSTEMI group were higher than those in non-NSTEMI group and control group[(8. 4 ± 1. 3)μg/L vs (7. 3 ± 1. 1),(3. 9 ± 0. 4)μg/L;(14. 7 ± 2. 0)％ vs (13. 4 ± 2. 1)％,(12. 1 ± 1. 9)％;(0. 59 ± 0. 08)μg/L vs (0. 31 ± 0. 04),(0. 09 ± 0. 01)μg/L] and the indexes in non-NSTEMI group were higher than those in control group(all P<0. 05). Levels of H-FABP, RDW and cTnT in severe group were higher than those in moderate group and mild group;the indexes in moderate group were higher than those in mild group(all P<0. 05). ROC curve analysis showed that the best cut-off points of H-FABP, RDW and cTnT were 8. 95 μg/L, 14. 73％, 0. 67μg/L and the areas under curve were 0. 750, 0. 742 and 0. 781, respectively;the area under curve of combined detection was 0.813. Conclusions H-FABP, RDW and cTnT are related to the severity of coronary artery lesion in patients with NSTEMI. Combined detection of the three indexes can improve early diagnosis of NSTEMI.
Keywords：Non-ST-segment elevation acute myocardial infarctionHeart-shaped fatty acid binding proteinRed blood cell volume distribution widthCardiac troponin TEarly diagnostic value
Publication Date：2020-04-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 499-503 )