Changes and significance of erythrocyte osmotic fragility in patients with ischemic cardiomyopathy
Cao Yuqing
Palidan Saimaiti
Zhang Huan
Sun Dagong
Wang Xifu
Abstract：Objective To investigate the changes of erythrocyte osmotic fragility in patients with ischemic cardiomyopathy(ICM), and to explore the possible mechanisms and clinical significances. Methods Eighty patients with ICM admitted to Beijing Anzhen Hospital, Capital Medical University from August 2017 to August 2019 were enrolled as observation group;30 healthy volunteers were enrolled as control group. Osmotic fragility of erythrocytes with different osmotic pressures, activity of Na+-K+-ATP enzyme on erythrocyte membrane, levels of plasma malonaldehyde(MDA) and superoxide dismutase(SOD) were analyzed. Results Before treatment, hemolysis rate of erythrocytes in gradient concentrations of sodium chloride solution ( 0. 81％, 0. 72％, 0. 63％, 0. 54％, 0. 45％, 0. 36％, 0. 27％, 0. 18％, 0. 09％) in the observation group were significantly higher than those in the control group, showing low erythrocyte osmotic fragility in ICM patients;hemolysis rate of erythrocytes decreased and the osmotic fragility were improved after treatment. Activity of Na+-K+-ATP enzyme was significantly lower and plasma MDA and SOD levels were higher in the observation group than those in the control group( all P<0. 01); these indexes were significantly improved in the observation group after treatment [(4. 69 ± 0.25) μmol/(mg·min) vs (1. 38 ± 0. 14) μmol/(mg·min),(5. 20 ± 1. 92) μmol/L vs (42. 10 ± 3.81) μmol/L,(18 ± 5) kNU/L vs (52 ± 8) kNU/L,all P < 0.01]. Conclusions Osmotic fragility of erythrocytes decreases in ICM patients, indicating poor deformability and ability to pass through microvessels, which inhibits myocardial tissue perfusion and causes cardiac insufficient blood supply. The reason of erythrocyte osmotic fragility reduction may be related to the decrease of Na+-K+-ATP enzyme activity and the enhancement of plasma lipid peroxidation.
Keywords：Ischemic cardiomyopathyErythrocyte osmotic fragilityClinical significance
Publication Date：2020-04-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 481-484 )