Therapeutic effect of ultrasound-guided percutaneous radiofrequency ablation on small primary hepatocellular carcinoma
Bai Jing
Zhang Li
Sun Hongwei
Du Jianwen
Abstract：Objective To investigate the clinical effect of ultrasound-guided percutaneous radiofreqnency ablation on small primary hepatocellular carcinoma.Methods From March 2015 to April 2016,100 patients with small primary hepatocellular carcinoma (diameter ≤ 3 cm) confirmed by pathological examination in the Third Hospital of Chengde City,Hebei Province were enrolled.They were randomly divided into control group and observation group,with 50 cases in each group.The control group underwent surgical resection.The observation group underwent ultrasound-guided percutaneous radiofrequency ablation.Operation time,intraoperative bleeding volume and hospitalization time were recorded.Levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase(AST) were detected before operation and 2,5 days after operation.Postoperative complications,recurrence rate and survival rate at 1,2,3 years after operation were observed.Results Operation time in the observation group was significantly shorter,amount of blood loss was significantly less and hospitalization time was significantly shorter than those in the control group [(23 ± 6) min vs (119 ± 23) min,(1.02 ± 0.12) ml vs (312.96 ± 125.88) ml,(6.5 ± 2.4) d vs (12.6 ± 4.2) d] (all P ＜ 0.001).Levels of ALT and AST significantly increased at 2 and 5 days after operation and reached the peak at 2 days;the levels in the observation group were significantly lower than those in the control group(all P ＜ 0.05).Incidence of postoperative complications in the observation group was significantly lower than that in the control group[16.0％ (8/50) vs 38.0％ (19/50)] (P =0.013).There were no significant differences in the 1-,2-,3-year recurrence rates and survival rates between groups (all P ＞ 0.05).Conclusion Ultrasound-guided percutaneous radiofrequency ablation is effective in treating small primary hepatocellular carcinoma(diameter≤3 cm);it can reduce surgical trauma and postoperative complications,promote liver function recovery and shorten the length of hospital stay.
Keywords：Small primary hepatocellular carcinomaUltrasonographyPercutaneous radiofrequency ablationLiver function
Publication Date：2020-01-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 71-74 )