Outcomes of different therapies treating high-risk children with abnormal nervous system development
Zhang Yang
Wang Lanying
Du Wenran
Qi Hao
Chen Chen
Abstract：Objective To analyze the effects of different treatment modes on high-risk children with abnormal nervous system development.Methods From March 2015 to January 2016,300 high-risk children with abnormal nervous system development admitted to Tangshan Maternal and Child Health Care Hospital,Hebei Province were randomly divided into 5 groups,with 60 cases in each group.Group A had simple exercise therapy;group B was treated with mouse nerve growth factor and exercise;group C was treated with cerebrovascular function therapy and exercise;group D was treated with sensory integration training and exercise;group E was treated with mouse nerve growth factor,cerebrovascular function therapy,sensory integration training and exercise.Therapeutic effect was observed after 9 months of treatment.Developmental quotient (DQ) of children was measured by the 0-6 years old neuropsychological scale after 3,6,9 months of treatment.Neurodevelopment was assessed by the 52-item neurological examination after 9 months of treatment.Results Total effective rate in group E was significantly higher than that in group A,B,C,D[88.3％ (53/60) vs 61.7％ (37/60),70.0％ (42/60),70.0％ (42/60),68.3 ％ (41/60)] (x2 =11.655,P =0.020).DQ showed no statistical difference among the 5 groups before treatment(P ＞ 0.05) and significantly increased after treatment(P ＜ 0.001);the values of DQ at 3,6,9 months after treatment in group E were significantly higher than those in group A,B,C,D(all P ＜ 0.05).Normal rate of neurodevelopment in group E was significantly higher than that in group A,B,C,D [75.0％ (45/60) vs 50.0％ (30/60),53.3％ (32/60),53.3％ (32/60),51.7％ (31/60)] (x2 =10.453,P =0.034).There were no significant differences in critical anomaly rate and abnormal rate of neurodevelopment among the 5 groups (x2 =4.621,5.222;P =0.328,0.265).Conclusion Exercise therapy combined with mouse nerve growth factor,cerebrovascular function therapy and sensory integration training can effectively promote neurodevelopment in children with abnormal nervous system development,and the therapeutic effect advances along with the duration of treatment.
Keywords：Abnormal nervous system developmentExercise therapyMouse nerve growth factorCerebrovascular function therapySensory integration training
Publication Date：2020-01-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 54-57 )