Clinical effect of amiodarone combined with irbesartan on chronic heart failure complicated with arrhythmia
Li Ya
Zhao Wenping
Feng Huiping
Wu Yanmin
Zu Yugang
Abstract：Objective To investigate the clinical effect of amiodarone combined with irbesartan on chronic heart failure complicated with arrhythmia.Methods A total of 82 patients with chronic heart failure and arrhythmia were enrolled from December 2016 to December 2017 in Affiliated Hospital of Hebei University.They were randomly divided into control group and observation group,with 41 cases in each group.The control group was treated with routine medication.The observation group was treated with amiodarone and irbesartan on the basis of routine medication.Cardiac function indexes,sinus rhythm maintenance rate after treatment and adverse reactions were analyzed.Results After treatment,cardiac output per minute and left ventricular ejection fraction were improved and the indexes in the observation group were significantly higher than those in the control group[(4.70 ± 0.25) L/min vs (4.19 ± 0.22) L/min,(50.6 ± 1.1) ％ vs (45.0 ± 0.9) ％];left ventricular end-diastolic and end-systolic dimensions diminished and the indexes in the observation group were significantly lower than those in the control group[(55.9 ±3.0)mm vs (60.0 ±3.1)mm,(51.1 ±2.2)mm vs (55.0±2.6)mm] (all P＜ 0.05).Sinus rhythm maintenance rates after 1,3 and 6 months of treatment in the observation group were significantly higher than those in the control group (all P ＜ 0.05).There was no significant difference in the incidence of adverse reactions between groups (P ＞ 0.05).Conclusion Amiodarone combined with irbesartan treating patients with chronic heart failure complicated with arrhythmia is effective in promoting sinus rhythm restoration and improving heat function.
Keywords：Heart failureArrhythmiaAmiodaroneIrbesartan
Publication Date：2020-01-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 26-29 )