Effect of tirofiban combined with nicorandil treating acute ST-segment elevation myocardial infarction patients undergoing emergency percutaneous coronary intervention on inflammatory response and cardiac function
Liu Chunli
Liang Yanhong
Xue Enzhong
He Jizhong
Abstract：Objective To investigate the clinical effect of tirofiban combined with nicorandil on acute ST-segment elevation myocardial infarction(STEMI) patients undergoing percutaneous coronary intervention(PCI) and the effect on serum inflammatory factors and cardiac function.Methods A total of 120 patients with STEMI undergoing PCI in Yan'an People's Hospital,Shaanxi Province from January 2016 to May 2018 were randomly divided into control group(60 cases) treated with tirofiban and observation group(60 cases) treated with tirofiban plus nicorandil.Serum levels of high-sensitivity C-reactive protein (hs-CRP),tumor necrosis factor-α (TNF-α) and interleukin-6(IL-6) were detected before and after PCI.Left ventricular end-diastolic volume(LVEDV),left ventricular ejection fraction(LVEF) and mitral early diastolic filling velocity(E)/late diastolic filling velocity(A) ratio were monitored at different time points after PCI.Main adverse cardiovascular events(MACE) within 90 days after procedure and bleeding events during treatment were observed.Results Serum levels of IL-6 at 24 h after PCI,hs-CRP,TNF-α and IL-6 at 7 d after PCI in observation group were significantly lower than those in observation group[(7.6±1.9)ng/L vs (8.6±1.8)ng/L,(5.3±0.8)mg/L vs (8.6±1.1)mg/L,(159±34)ng/L vs (211±43)ng/L,(3.0±1.2)ng/L vs (3.7±1.2)ng/L] (all P ＜0.05).At 90 d after PCI,LVEDV in observation group was significantly lower and LVEF,E/A ratio were higher than those in control group [(85 ± 9)mlvs (92±9)ml,(60 ±5)％ vs (56 ±6)％,(1.2 ±0.3) vs (0.9±0.3)] (all P＜0.05).LVEDV increased and LVEF,E/A decreased at 90 d in both groups compared with those at 24 h after PCI (all P ＜ 0.05).There were no statistical differences in the 90 d MACE and bleeding events between groups (P =0.327,P =1.000).Conclusion Tirofiban combined with nicorandil treating STEMI patients can significantly reduce inflammation and protect left ventricular function after PCI.
Keywords：ST-segment elevation myocardial infarctionTirofibanNicorandilPercutaneous coronary interventionInflammatory factors
Publication Date：2020-01-08
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 22-25 )