Correlation between blood pressure variability and coronary artery calcification in people with normal blood pressure

Zhang Yu; Zhou Yujie; Wang Zhijian; Han Hongya

doi:10.3760/j.issn.1673-4777.2020.01.001

Abstract：Objective To investigate the correlation between blood pressure variability (BPV) and coronary artery calcification in people with normal blood pressure.Methods From January 2016 to June 2019,152 patients with normal blood pressure were enrolled in Beijing Anzhen Hospital,Capital Medical University.All patients had spiral CT coronary artery imaging and 24 h ambulatory blood pressure monitoring.According to the coronary artery calcification score(CACS),the patients were divided into 5 groups:non-calcification group,CACS =0,57 cases;minimal calcification group,CACS≤10,26 cases;mild calcification group,10 ＜ CACS≤100,23 cases;moderate calcification group,100 ＜ CACS ≤ 400,17 cases;severe calcification group,CACS ＞ 400,29 cases.Correlation between CACS and BPV and the influencing factors of CACS were analyzed.Results Levels of 24 h standard deviation of systolic pressure(24 h SSD),daytime standard deviation of systolic pressure(dSSD),weighted standard deviation of systolic pressure (SwSD),24 h variation coefficient of systolic pressure (24 h SCV) and daytime variation coefficient of systolic pressure(dSCV) in the severe calcification group were significantly higher than those in the other 4 groups(all P ＜ 0.05).CACS was positively correlated with 24 h SSD,dSSD,24 h SCV,dSCV and SwSD(r =0.289,0.284,0.218,0.226,0.252;P ＜0.001,＜0.001,0.007,0.005,0.002).Multiple logistic regression analysis showed that smoking,24 h SSD,dSSD,24 h SCV,dSCV and SwSD were influencing factors of CACS(odds ratio=l.426,6.210,1.911,2.071,1.260,3.728;all P＜0.05).Conclusion Systolic blood pressure variability,especially daytime variability,is correlated with coronary artery calcification in normal blood pressure population;the severity of coronary artery calcification increases with abnormal systolic blood pressure variability.