Influence of different treatment plans on blood glucose control in type 2 diabetic patients after short-term intensive insulin treatment
Zhou Guangju
Cui Jiale
Li Yizhen
Cui Sufen
Xie Suhua
Yang Qiu
Huang Fengjiao
Wang Yan
Abstract：Objective To explore the influence of different treatment plans following short-term intensive insulin therapy on blood glucose control in patients with type 2 diabetes.Methods Totally 200 patients with type 2 diabetes who had short-term intensive insulin therapy in Affiliated Hospital of North Sichuan Medical College from March 2016 to February 2018 were randomly assigned to have different subsequent treatment plans:oral melbine (66 cases),premixed insulin(67 cases) and basal insulin + melbine(67 cases).All patients were followed up for 1 year,the long-term blood glucose control effect,homeostasis model assessment of insulin resistance index (HOMA-IR),body mass index,the ratio of insulin to blood glucose increment(△I30/△G30) were observed.Results The 1-year remission rate with premixed insulin and basal insulin + melbine was significantly higher than with melbine[76.1％ (51/67),82.1％ (55/67) vs 57.6％ (38/66)] (both P ＜0.05),but there was no statistical difference between premixed insulin and basal insulin + melbine(P ＞ 0.05).△t the end of 1-year follow-up,levels of fasting blood glucose,postprandial 2 h blood glucose and glycosylated hemoglobin were significandy improved in all patients [(6.8 ± 2.6) mmol/L vs (5.1 ± 1.4),(5.0 ± 1.3) mmol/L;(10.6 ± 2.1) mmoL/L vs (7.2 ± 2.3),(7.2 ± 2.4) mmol/L;(7.8 ± 1.3) ％ vs (6.9 ± 1.3) ％,(6.8 ± 1.1) ％] (all P ＜ 0.05);the indexes with melbine were significantly higher than with premixed insulin and basal insulin + melbine;there was no statistical difference between premixed insulin and basal insulin + melbine(all P ＞ 0.05).HOMA-IR and body mass index significantly decreased and △I30/△G30 increased after follow-up (P ＜ 0.05);HOMA-IR and body mass index decreased and △I30/△G30 increased among melbine,premixed insulin and basal insulin + melbine,with significant differences among them (P ＜ 0.05).Conclusions Premixed insulin or basal insulin + oral hypoglycemic agent treating type 2 diabetic patients after intensive insulin treatment shows better clinical efficacy than taking oral hypoglycemic agent alone.Basal insulin + oral hypoglycemic agent has equal effect with premixed insulin on blood glucose control,but it is superior in improving the function of islet β cells.
Keywords：Type 2 diabetes mellitusIntensive therapyMetforminInsulin sensitizerBlood glucose
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1813-1817 )