Effect of salbutamol combined with methylprednisolone on high sensitive C-reactive protein, N-terminal pro-brain natriuretic peptide and heart function in patients with type Ⅱ respiratory failure

Zhou Zhixiang; Zhan Maoqin; Jiang Tao

doi:10.3760/j.issn.1673-4777.2019.12.008

Abstract：Objective To observe the effect of salbutamol combined with methylprednisolone on the levels of high sensitive C-reactive protein(hs-CRP),N-terminal pro-brain natriuretic peptide(NT-proBNP) and heart function in patients with type]Ⅱ respiratory failure.Methods A total of 102 patients with type Ⅱ respiratory failure who were hospitalized in the People's Hospital of Xuancheng City,Anhui Province from June 2017 to December 2018 were randomly divided into routine group and combination group,with 51 cases in each group.The routine group were given routine oxygen inhalation,expectoration and anti-infection treatments.The combination group was additionally given salbutamol and methylprednisolone.After 10 days of treatment,blood gas indicators,levels of serum hs-CRP and NT-proBNP,heart function indexes,score of Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) and adverse reactions were analyzed.Results After treatment,oxygenation index,arterial partial pressure of oxygen and pH significantly increased in both groups and the indexes in the combination group were higher than those in the routine group;arterial partial pressure of carbon dioxide,serum levels of hs-CRP and NT-proBNP significantly decreased and the indexes in the combination group were lower than those in the routine group[(37 ± 7) mmHg vs (48 ± 8) mmHg,(13.8 ± 2.5) mg/L vs (18.9 ± 3.5) mg/L,(512 ±89) ng/L vs (649 ± 106) ng/L] (all P ＜ 0.05).After treatment,left ventricular end-diastolic and end-systolic diameters diminished and left ventricular ejection fraction increased in both groups;left ventricular end-diastolic and end-systolic diameters in the combination group were lower and left ventricular ejection fraction[(45 ± 7)％ vs (40 ± 7) ％] was higher than those in the routine group (all P ＜ 0.05).APACHE Ⅱ score significantly decreased after treatment and it was lower in the combination group than that in the routine group[(10.1 ± 1.9)scores vs (15.8 ± 2.9)scores] (all P ＜ 0.05).There was no statistical difference in the incidence rate of adverse reactions between groups(P ＞ 0.05).Conclusion Salbutamol combined with methylprednisolone treating type Ⅱ respiratory failure can significantly improve blood gas indicatorss,reduce serum hs-CRP and NT-proBNP levels,alleviate cardiac load,improve the quality of life and prognosis of patient.