Therapeutic effect of nicorandil on patients with acute myocardial infarction undergoing percutaneous coronary intervention
Cui Xiaoyan
Wang Sheng
Gen Yunguang
Wang Taihao
Tian Xulu
Abstract：Objective To investigate the effect of nicorandil on left ventricular function,serum cystatin C and inflammatory factors in patients with acute myocardial infarction undergoing percutaneous coronary intervention (PCI).Methods A total of 89 patients with acute myocardial infarction admitted to Hainan General Hospital from February 2017 to August 2018 were randomly divided into observation group(45 patients) and control group (44 patients).The control group was treated with conventional drugs and the observation group took nicorandil additionally for 1 month.Left ventricular function and myocardial enzyme indexes,serum levels of cystatin C and inflammatory factors were detected 1 week and 1 month after PCI.Results There were no statistical differences in left ventricular function,myocardial enzymes,serum cystatin C and inflammatory factors between groups at 1 week after PCI.One month after PCI,left ventricular ejection fraction and cardiac index in the observation group were significantly higher and left ventricular end-diastolic and end-systolic volume indexes were significantly lower than those in the control group[(53.1 ±3.4)％ vs (47.7 ±3.4)％,(2.83 ±0.54)L/(min · m2) vs (2.52 ±0.47)L/(min · m2),(91 ± 12)ml/m2 vs (104 ± 13)ml/m2,(48 ±6)ml/m2 vs (52 ±8)ml/m2] (all P＜0.05).Plasma levels of creatine kinase and lactate dehydrogenase decreased at 1 month as compared with 1 week after operation,and the levels in the observation group were significantly lower than those in the control group [(57 ±6)kU/L vs (65 ±7)kU/L,(5 815 ±472)U/L vs (6 357 ±522)U/L] (all P ＜0.05).Levels of serum cystatin C,tumor necrosis factor-α and interleukin-17 decreased at 1 month as compared with 1 week after operation and they were lower in the observation group than those in the control group [(2.12 ± 0.26) mg/L vs (3.53 ±0.44)mg/L,(107 ±35)ng/L vs (128 ±49) ng/L,(280 ± 34) μg/L vs (302 ±35) μg/L];serum interleukin-10 level increased at 1 month after operation and it was higher in the observation group than that in the control group[(18.9 ± 2.2) μg/L vs (16.8 ± 4.3) μg/L] (all P ＜ 0.05).Conclusion Nicorandil can effectively enhance myocardial function,reduce plasma creatine kinase and lactate dehydrogenase,improve serum cystatin C and inflammatory factors after PCI for acute myocardial infarction.
Keywords：Acute myocardial infarctionNicorandilCystatin CInflammatory factor
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1765-1768 )