Clinical effect of laparoscopic radical resection of colorectal cancer and the effect on coagulation function and T lymphocyte level

Wang Zhao; Peng Lintao; Yang Fan; Li Bin

doi:10.3760/j.issn.1673-4777.2019.11.020

Abstract：Objective To analyze the clinical effect of laparoscopic radical resection of colorectal cancer and the effect on coagulation function and T lymphocyte level,providing reference for clinical treatment.Methods A total of 170 patients with colorectal cancer were enrolled from June 2016 to December 2018 at Xingtai People's Hospital,Hebei Province.They were randomly divided into observation group and control group,with 85 cases in each group.The control group underwent routine open surgery,while the observation group underwent laparoscopic radical resection of colorectal cancer.Clinical effect,coagulation function,T lymphocyte level and postoperative ultrasonic results of lower extremities were analyzed.Results Operation time,intraoperative blood loss,duration time of abdominal distension and anal exhaust time in observation group were significantly shorter/less than those in control group;levels of motilin and gastrin postoperative in observation group were significantly higher than those in control group[(113 ± 16)min vs (185 ± 24) min,(50 ±9)ml vs (95 ± 12)ml,(3.3 ±0.5)d vs (4.8 ±0.6)d,(2.9 ±0.8)d vs (4.1 ±0.9)d,(80 ±7) ng/L vs (59 ± 13) ng/L,(227 ± 32) ng/L vs (146 ±24)ng/L] (all P ＜ 0.05).There were no significant difference in coagulation function indexes between groups before and after treatment (all P ＞ 0.05).At 24 h after operation,levels of CD3+,CD4+ and CD8+ were significantly lower than those at 24 h before treatment in both groups;the levels in observation group were lower than those in control group[(33 ±4)％ vs (42 ±5)％,(24 ±6)％ vs (34 ±4)％,(20 ±3)％ vs (29 ±3)％](all P ＜ 0.05).No thrombosis was observed in veins of lower extremities by ultrasonography after operation.Conclusion Laparoscopic radical resection of colorectal cancer has good clinical effect without affecting coagulation function and is conducive to the recovery of immune function.